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Diet and Alzheimer's disease.
Curr Neurol Neurosci Rep 2007; 7(5):366-72CN

Abstract

Alzheimer's disease (AD) is increasing in prevalence. There are no known preventive or curative measures. There is evidence that oxidative stress, homo-cysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Some epidemiologic studies suggest that higher dietary intake of antioxidants, vitamins B(6), B(12), and folate, unsaturated fatty acids, and fish are related to a lower risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a lower risk of AD. The Mediterranean diet may also be related to lower AD risk. However, randomized clinical trials of supplements of vitamins E, B(12), B(6), and folate have shown no cognitive benefit, and randomized trials for other nutrients or diets in AD are not available. The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD.

Authors+Show Affiliations

Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University, PH9E-105, 630 West 168th Street, New York, NY 10032, USA. jal94@columbia.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17764625

Citation

Luchsinger, José A., et al. "Diet and Alzheimer's Disease." Current Neurology and Neuroscience Reports, vol. 7, no. 5, 2007, pp. 366-72.
Luchsinger JA, Noble JM, Scarmeas N. Diet and Alzheimer's disease. Curr Neurol Neurosci Rep. 2007;7(5):366-72.
Luchsinger, J. A., Noble, J. M., & Scarmeas, N. (2007). Diet and Alzheimer's disease. Current Neurology and Neuroscience Reports, 7(5), pp. 366-72.
Luchsinger JA, Noble JM, Scarmeas N. Diet and Alzheimer's Disease. Curr Neurol Neurosci Rep. 2007;7(5):366-72. PubMed PMID: 17764625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and Alzheimer's disease. AU - Luchsinger,José A, AU - Noble,James M, AU - Scarmeas,Nikolaos, PY - 2007/9/4/pubmed PY - 2007/12/6/medline PY - 2007/9/4/entrez SP - 366 EP - 72 JF - Current neurology and neuroscience reports JO - Curr Neurol Neurosci Rep VL - 7 IS - 5 N2 - Alzheimer's disease (AD) is increasing in prevalence. There are no known preventive or curative measures. There is evidence that oxidative stress, homo-cysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Some epidemiologic studies suggest that higher dietary intake of antioxidants, vitamins B(6), B(12), and folate, unsaturated fatty acids, and fish are related to a lower risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a lower risk of AD. The Mediterranean diet may also be related to lower AD risk. However, randomized clinical trials of supplements of vitamins E, B(12), B(6), and folate have shown no cognitive benefit, and randomized trials for other nutrients or diets in AD are not available. The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD. SN - 1528-4042 UR - https://www.unboundmedicine.com/medline/citation/17764625/Diet_and_Alzheimer's_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17764625.ui DB - PRIME DP - Unbound Medicine ER -