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Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency.
Trans R Soc Trop Med Hyg. 2007 Nov; 101(11):1106-13.TR

Abstract

The incidence of dengue fever (DF) is estimated to have increased 30-fold in the past 50 years. The incidence of dengue haemorrhagic fever (DHF), a life-threatening complication of DF, is also increasing. The need for better classification of the severity of dengue infections has been proposed in order to clarify different entities of dengue infections. We defined a class of patients with DF with bleeding tendency (DF w/B) to differentiate further the varying pathogenesis among DF, DF w/B and DHF. In a hospital-based study in Taiwan, we compared clinical features, biochemistry and immune mediators among patients with DHF, DF w/B and DF. Results showed that DF w/B patients, similar to DHF patients, had a higher rate of secondary dengue infection (P<0.001) as well as higher IL-10 (P=0.023) and lower IFNgamma (P=0.009) levels than DF patients. In contrast, DHF patients had significantly higher soluble vascular cell adhesion molecule 1 levels than DF w/B patients (P=0.038) and DF patients (P<0.001). This study provides new insight into the different immune mechanisms of DF, DF w/B and DHF. DF involves a Th1 reaction and DF w/B involves an altered Th2 reaction, whereas DHF involves an altered Th2 reaction and augmented vascular insult.

Authors+Show Affiliations

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17764712

Citation

Chen, Rong-Fu, et al. "Different Clinical and Laboratory Manifestations Between Dengue Haemorrhagic Fever and Dengue Fever With Bleeding Tendency." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 101, no. 11, 2007, pp. 1106-13.
Chen RF, Yang KD, Wang L, et al. Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency. Trans R Soc Trop Med Hyg. 2007;101(11):1106-13.
Chen, R. F., Yang, K. D., Wang, L., Liu, J. W., Chiu, C. C., & Cheng, J. T. (2007). Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(11), 1106-13.
Chen RF, et al. Different Clinical and Laboratory Manifestations Between Dengue Haemorrhagic Fever and Dengue Fever With Bleeding Tendency. Trans R Soc Trop Med Hyg. 2007;101(11):1106-13. PubMed PMID: 17764712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency. AU - Chen,Rong-Fu, AU - Yang,Kuender D, AU - Wang,Lin, AU - Liu,Jien-Wei, AU - Chiu,Chi-Chin, AU - Cheng,Jiin-Tsuey, Y1 - 2007/08/30/ PY - 2007/02/17/received PY - 2007/06/29/revised PY - 2007/06/29/accepted PY - 2007/9/4/pubmed PY - 2008/3/4/medline PY - 2007/9/4/entrez SP - 1106 EP - 13 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 101 IS - 11 N2 - The incidence of dengue fever (DF) is estimated to have increased 30-fold in the past 50 years. The incidence of dengue haemorrhagic fever (DHF), a life-threatening complication of DF, is also increasing. The need for better classification of the severity of dengue infections has been proposed in order to clarify different entities of dengue infections. We defined a class of patients with DF with bleeding tendency (DF w/B) to differentiate further the varying pathogenesis among DF, DF w/B and DHF. In a hospital-based study in Taiwan, we compared clinical features, biochemistry and immune mediators among patients with DHF, DF w/B and DF. Results showed that DF w/B patients, similar to DHF patients, had a higher rate of secondary dengue infection (P<0.001) as well as higher IL-10 (P=0.023) and lower IFNgamma (P=0.009) levels than DF patients. In contrast, DHF patients had significantly higher soluble vascular cell adhesion molecule 1 levels than DF w/B patients (P=0.038) and DF patients (P<0.001). This study provides new insight into the different immune mechanisms of DF, DF w/B and DHF. DF involves a Th1 reaction and DF w/B involves an altered Th2 reaction, whereas DHF involves an altered Th2 reaction and augmented vascular insult. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/17764712/Different_clinical_and_laboratory_manifestations_between_dengue_haemorrhagic_fever_and_dengue_fever_with_bleeding_tendency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(07)00232-5 DB - PRIME DP - Unbound Medicine ER -