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Breast-feeding and atopic disease: a cohort study from childhood to middle age.
J Allergy Clin Immunol. 2007 Nov; 120(5):1051-7.JA

Abstract

BACKGROUND

The literature regarding the association between breast-feeding and atopic diseases has been contradictory.

OBJECTIVE

We have assessed the relationship between breast-feeding and atopic disorders in a cohort followed into middle age.

METHODS

The Tasmanian Asthma Study is a population-based prospective cohort study that has followed participants from the age of 7 to 44 years. Exclusive breast-feeding in the first 3 months of life was examined as a risk factor for atopic diseases by using multiple logistic regression and generalized estimating equation analyses.

RESULTS

At age 7 years, exclusively breast-fed children with a maternal history of atopy had a marginally lesser risk of current asthma than those not exclusively breast-fed (odds ratio [OR], 0.8; 95% CI, 0.6-1.0). However, after age 7 years, the risk reversed, and exclusively breast-fed children had an increased risk of current asthma at 14 (OR, 1.46; 95% CI, 1.02-2.07), 32 (OR, 1.84; 95% CI, 1.06-3.3), and 44 (OR, 1.57; 95% CI, 1.15-2.14) years. Exclusively breast-fed children also had a reduced risk of food allergy at age 7 years but an increased risk of food allergy (OR, 1.26; 95% CI, 1.1-1.5) and allergic rhinitis (OR, 1.2; 95% CI, 1.0-1.3) at 44 years.

CONCLUSION

Exclusively breast-fed babies with a maternal history of atopy were less likely to develop asthma before the age of 7 years, but more likely to develop asthma after the age of 7 years.

CLINICAL IMPLICATIONS

The current recommendation to breast-feed high-risk infants for protection against early wheezing illness can be confirmed. However, the recommendation should be reconsidered for protection against allergic asthma and atopy in the longer term.

Authors+Show Affiliations

Center for Molecular, Environmental, Genetic & Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Australia. mcmat@unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17764732

Citation

Matheson, Melanie Claire, et al. "Breast-feeding and Atopic Disease: a Cohort Study From Childhood to Middle Age." The Journal of Allergy and Clinical Immunology, vol. 120, no. 5, 2007, pp. 1051-7.
Matheson MC, Erbas B, Balasuriya A, et al. Breast-feeding and atopic disease: a cohort study from childhood to middle age. J Allergy Clin Immunol. 2007;120(5):1051-7.
Matheson, M. C., Erbas, B., Balasuriya, A., Jenkins, M. A., Wharton, C. L., Tang, M. L., Abramson, M. J., Walters, E. H., Hopper, J. L., & Dharmage, S. C. (2007). Breast-feeding and atopic disease: a cohort study from childhood to middle age. The Journal of Allergy and Clinical Immunology, 120(5), 1051-7.
Matheson MC, et al. Breast-feeding and Atopic Disease: a Cohort Study From Childhood to Middle Age. J Allergy Clin Immunol. 2007;120(5):1051-7. PubMed PMID: 17764732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding and atopic disease: a cohort study from childhood to middle age. AU - Matheson,Melanie Claire, AU - Erbas,Bircan, AU - Balasuriya,Aindralal, AU - Jenkins,Mark Andrew, AU - Wharton,Cathryn Leisa, AU - Tang,Mimi Lai-Kuan, AU - Abramson,Michael John, AU - Walters,Eugene Haydn, AU - Hopper,John Llewelyn, AU - Dharmage,Shyamali Chandrika, Y1 - 2007/08/31/ PY - 2006/10/25/received PY - 2007/06/11/revised PY - 2007/06/12/accepted PY - 2007/9/4/pubmed PY - 2008/2/5/medline PY - 2007/9/4/entrez SP - 1051 EP - 7 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 120 IS - 5 N2 - BACKGROUND: The literature regarding the association between breast-feeding and atopic diseases has been contradictory. OBJECTIVE: We have assessed the relationship between breast-feeding and atopic disorders in a cohort followed into middle age. METHODS: The Tasmanian Asthma Study is a population-based prospective cohort study that has followed participants from the age of 7 to 44 years. Exclusive breast-feeding in the first 3 months of life was examined as a risk factor for atopic diseases by using multiple logistic regression and generalized estimating equation analyses. RESULTS: At age 7 years, exclusively breast-fed children with a maternal history of atopy had a marginally lesser risk of current asthma than those not exclusively breast-fed (odds ratio [OR], 0.8; 95% CI, 0.6-1.0). However, after age 7 years, the risk reversed, and exclusively breast-fed children had an increased risk of current asthma at 14 (OR, 1.46; 95% CI, 1.02-2.07), 32 (OR, 1.84; 95% CI, 1.06-3.3), and 44 (OR, 1.57; 95% CI, 1.15-2.14) years. Exclusively breast-fed children also had a reduced risk of food allergy at age 7 years but an increased risk of food allergy (OR, 1.26; 95% CI, 1.1-1.5) and allergic rhinitis (OR, 1.2; 95% CI, 1.0-1.3) at 44 years. CONCLUSION: Exclusively breast-fed babies with a maternal history of atopy were less likely to develop asthma before the age of 7 years, but more likely to develop asthma after the age of 7 years. CLINICAL IMPLICATIONS: The current recommendation to breast-feed high-risk infants for protection against early wheezing illness can be confirmed. However, the recommendation should be reconsidered for protection against allergic asthma and atopy in the longer term. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/17764732/Breast_feeding_and_atopic_disease:_a_cohort_study_from_childhood_to_middle_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(07)01252-3 DB - PRIME DP - Unbound Medicine ER -