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Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study.
Schizophr Res 2007; 97(1-3):51-9SR

Abstract

A range of complications of pregnancy, abnormal fetal growth and development, and complications of delivery have been associated with increased risk of schizophrenia. Few studies have been able to adjust for a broad range of potential confounding factors. A national population nested case-control study based on Danish longitudinal registers was conducted to investigate the risk of schizophrenia associated with exposure to a range of obstetric events. The sample included 1039 first admissions to, or contacts with Danish psychiatric services with an ICD-8 or ICD-10 diagnosis of schizophrenia and 24, 826 individually matched controls. Adjusting for the other obstetric factors, family psychiatric history, and socio-economic and demographic factors, risk of schizophrenia was associated with maternal non-attendance at antenatal appointments (Incidence Rate Ratio (IRR) 2.08, 95% CI: 1.0, 4.4), gestational age of 37 weeks or below (IRR 1.51, 95% CI: 1.0, 2.2), maternal influenza (IRR 8.2, 95% CI: 1.4, 48.8), preeclampsia (IRR 2.72, 95% CI: 1.0, 7.3), threatened premature delivery (IRR 2.39, 95% CI: 1.4, 4.1), haemorrhage during delivery (IRR 2.43, 95% CI: 1.1, 5.6), manual extraction of the baby (IRR 2.15, 95% CI: 1.1, 4.4), and maternal sepsis of childbirth and the puerperium (IRR 2.91, 95% CI: 1.1, 7.9). There was no significant interaction between the obstetric factors and either sex or family psychiatric history. The data suggest a modest association between prematurity, indicators of hypoxia, maternal infections, and maternal behaviours and risk of the later development of schizophrenia after adjusting for a number of possible confounding factors.

Authors+Show Affiliations

National Centre for Register-based Research, Aarhus University, Taasingegade 1, Aarhus 8000 C, Denmark. mb@ncrr.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17764905

Citation

Byrne, Majella, et al. "Obstetric Conditions and Risk of First Admission With Schizophrenia: a Danish National Register Based Study." Schizophrenia Research, vol. 97, no. 1-3, 2007, pp. 51-9.
Byrne M, Agerbo E, Bennedsen B, et al. Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study. Schizophr Res. 2007;97(1-3):51-9.
Byrne, M., Agerbo, E., Bennedsen, B., Eaton, W. W., & Mortensen, P. B. (2007). Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study. Schizophrenia Research, 97(1-3), pp. 51-9.
Byrne M, et al. Obstetric Conditions and Risk of First Admission With Schizophrenia: a Danish National Register Based Study. Schizophr Res. 2007;97(1-3):51-9. PubMed PMID: 17764905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study. AU - Byrne,Majella, AU - Agerbo,Esben, AU - Bennedsen,Birgit, AU - Eaton,William W, AU - Mortensen,Preben Bo, Y1 - 2007/08/31/ PY - 2006/01/04/received PY - 2007/07/17/revised PY - 2007/07/25/accepted PY - 2007/9/4/pubmed PY - 2008/3/5/medline PY - 2007/9/4/entrez SP - 51 EP - 9 JF - Schizophrenia research JO - Schizophr. Res. VL - 97 IS - 1-3 N2 - A range of complications of pregnancy, abnormal fetal growth and development, and complications of delivery have been associated with increased risk of schizophrenia. Few studies have been able to adjust for a broad range of potential confounding factors. A national population nested case-control study based on Danish longitudinal registers was conducted to investigate the risk of schizophrenia associated with exposure to a range of obstetric events. The sample included 1039 first admissions to, or contacts with Danish psychiatric services with an ICD-8 or ICD-10 diagnosis of schizophrenia and 24, 826 individually matched controls. Adjusting for the other obstetric factors, family psychiatric history, and socio-economic and demographic factors, risk of schizophrenia was associated with maternal non-attendance at antenatal appointments (Incidence Rate Ratio (IRR) 2.08, 95% CI: 1.0, 4.4), gestational age of 37 weeks or below (IRR 1.51, 95% CI: 1.0, 2.2), maternal influenza (IRR 8.2, 95% CI: 1.4, 48.8), preeclampsia (IRR 2.72, 95% CI: 1.0, 7.3), threatened premature delivery (IRR 2.39, 95% CI: 1.4, 4.1), haemorrhage during delivery (IRR 2.43, 95% CI: 1.1, 5.6), manual extraction of the baby (IRR 2.15, 95% CI: 1.1, 4.4), and maternal sepsis of childbirth and the puerperium (IRR 2.91, 95% CI: 1.1, 7.9). There was no significant interaction between the obstetric factors and either sex or family psychiatric history. The data suggest a modest association between prematurity, indicators of hypoxia, maternal infections, and maternal behaviours and risk of the later development of schizophrenia after adjusting for a number of possible confounding factors. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/17764905/Obstetric_conditions_and_risk_of_first_admission_with_schizophrenia:_a_Danish_national_register_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(07)00316-7 DB - PRIME DP - Unbound Medicine ER -