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High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis.
J Clin Virol. 2007 Oct; 40(2):116-9.JC

Abstract

BACKGROUND

Diverticulitis affects 10% of the western population and is characterized by microscopic inflammation of the colon. Increasing evidence suggests that human cytomegalovirus (HCMV) is an important pathogen in various inflammatory diseases. We hypothesized that HCMV contributes to the progression of diverticulitis, especially in immunocompromised patients in whom HCMV is a significant pathogen.

OBJECTIVES

To determine if HCMV is associated with diverticulitis and with an increased frequency of diverticulitis complications.

STUDY DESIGN

We examined the prevalence of an active HCMV infection in 23 patients with diverticulitis. Serum samples were analyzed for the presence of HCMV-IgG and HCMV-IgM antibodies in 11 of these patients. Immunohistochemistry was used for detection of HCMV early antigens in intestinal paraffin tissue sections obtained from the diverticulitis patients.

RESULTS

HCMV-early proteins could be detected in intestinal cells in 16/23 (69.6%) patients with diverticulitis. All of the 11 patients with serum samples were HCMV-IgG positive and 2 of these were also HCMV-IgM positive.

CONCLUSION

Active HCMV infection is frequently associated with diverticulitis and could contribute to the inflammatory process characteristic of diverticulitis.

Authors+Show Affiliations

Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17765008

Citation

Hollink, N, et al. "High Prevalence of an Active Human Cytomegalovirus Infection in Patients With Colonic Diverticulitis." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 40, no. 2, 2007, pp. 116-9.
Hollink N, Dzabic M, Wolmer N, et al. High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis. J Clin Virol. 2007;40(2):116-9.
Hollink, N., Dzabic, M., Wolmer, N., Boström, L., & Rahbar, A. (2007). High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 40(2), 116-9.
Hollink N, et al. High Prevalence of an Active Human Cytomegalovirus Infection in Patients With Colonic Diverticulitis. J Clin Virol. 2007;40(2):116-9. PubMed PMID: 17765008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis. AU - Hollink,N, AU - Dzabic,M, AU - Wolmer,N, AU - Boström,L, AU - Rahbar,A, Y1 - 2007/08/30/ PY - 2007/04/28/received PY - 2007/07/18/revised PY - 2007/07/18/accepted PY - 2007/9/4/pubmed PY - 2007/12/14/medline PY - 2007/9/4/entrez SP - 116 EP - 9 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 40 IS - 2 N2 - BACKGROUND: Diverticulitis affects 10% of the western population and is characterized by microscopic inflammation of the colon. Increasing evidence suggests that human cytomegalovirus (HCMV) is an important pathogen in various inflammatory diseases. We hypothesized that HCMV contributes to the progression of diverticulitis, especially in immunocompromised patients in whom HCMV is a significant pathogen. OBJECTIVES: To determine if HCMV is associated with diverticulitis and with an increased frequency of diverticulitis complications. STUDY DESIGN: We examined the prevalence of an active HCMV infection in 23 patients with diverticulitis. Serum samples were analyzed for the presence of HCMV-IgG and HCMV-IgM antibodies in 11 of these patients. Immunohistochemistry was used for detection of HCMV early antigens in intestinal paraffin tissue sections obtained from the diverticulitis patients. RESULTS: HCMV-early proteins could be detected in intestinal cells in 16/23 (69.6%) patients with diverticulitis. All of the 11 patients with serum samples were HCMV-IgG positive and 2 of these were also HCMV-IgM positive. CONCLUSION: Active HCMV infection is frequently associated with diverticulitis and could contribute to the inflammatory process characteristic of diverticulitis. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/17765008/High_prevalence_of_an_active_human_cytomegalovirus_infection_in_patients_with_colonic_diverticulitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(07)00257-0 DB - PRIME DP - Unbound Medicine ER -