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Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat.
Brain Res. 2007 Oct 10; 1173:84-91.BR

Abstract

We examined the distribution and origin of the nerve fibers innervating the dura mater of the rat that show immunoreactivity for the TRPV1 receptor (TRPV1-IR). Nearly 70% of the nerve fibers showing TRPV1-IR in the dura mater also exhibited CGRP-IR. Using a combination of immunohistochemistry and a retrograde tracer technique, we detected tracer accumulation in 0.6% of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- and medium-sized (<or=1000 microm2). Among the tracer-accumulated neurons in the trigeminal ganglion, approximately 25% exhibited TRPV1-IR. Furthermore, nearly 80% of the tracer-accumulated small- and medium-sized neurons in the trigeminal ganglion that exhibited TRPV1-IR also exhibited CGRP-IR. Our findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine.

Authors+Show Affiliations

Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo, 160-8582, Japan. shimizu-toshi@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17765209

Citation

Shimizu, Toshihiko, et al. "Distribution and Origin of TRPV1 Receptor-containing Nerve Fibers in the Dura Mater of Rat." Brain Research, vol. 1173, 2007, pp. 84-91.
Shimizu T, Toriumi H, Sato H, et al. Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. Brain Res. 2007;1173:84-91.
Shimizu, T., Toriumi, H., Sato, H., Shibata, M., Nagata, E., Gotoh, K., & Suzuki, N. (2007). Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. Brain Research, 1173, 84-91.
Shimizu T, et al. Distribution and Origin of TRPV1 Receptor-containing Nerve Fibers in the Dura Mater of Rat. Brain Res. 2007 Oct 10;1173:84-91. PubMed PMID: 17765209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. AU - Shimizu,Toshihiko, AU - Toriumi,Haruki, AU - Sato,Hideki, AU - Shibata,Mamoru, AU - Nagata,Eiichiro, AU - Gotoh,Kyoko, AU - Suzuki,Norihiro, Y1 - 2007/08/10/ PY - 2007/03/22/received PY - 2007/07/30/revised PY - 2007/07/30/accepted PY - 2007/9/4/pubmed PY - 2008/1/10/medline PY - 2007/9/4/entrez SP - 84 EP - 91 JF - Brain research JO - Brain Res VL - 1173 N2 - We examined the distribution and origin of the nerve fibers innervating the dura mater of the rat that show immunoreactivity for the TRPV1 receptor (TRPV1-IR). Nearly 70% of the nerve fibers showing TRPV1-IR in the dura mater also exhibited CGRP-IR. Using a combination of immunohistochemistry and a retrograde tracer technique, we detected tracer accumulation in 0.6% of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- and medium-sized (<or=1000 microm2). Among the tracer-accumulated neurons in the trigeminal ganglion, approximately 25% exhibited TRPV1-IR. Furthermore, nearly 80% of the tracer-accumulated small- and medium-sized neurons in the trigeminal ganglion that exhibited TRPV1-IR also exhibited CGRP-IR. Our findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/17765209/Distribution_and_origin_of_TRPV1_receptor_containing_nerve_fibers_in_the_dura_mater_of_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(07)01794-5 DB - PRIME DP - Unbound Medicine ER -