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Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum.
Fertil Steril. 2008 Jul; 90(1):148-55.FS

Abstract

OBJECTIVE

To analyze vascular density and immunolocalization of angiogenic vascular endothelial growth factor (VEGF) and its receptor Flk-1 in the proliferative and secretory eutopic human endometrium and in three different sites of endometriosis: the ovary, bladder, and rectum.

DESIGN

Prospective study.

SETTING

University hospital.

PATIENT(S)

Thirty women with endometriosis (10 ovarian, 10 bladder, 10 rectal) and 32 control women (10 proliferative endometrium, 10 secretory endometrium, 4 normal ovary, 4 normal bladder, 4 normal rectum).

INTERVENTION(S)

Normal endometrial samples were obtained from women during laparoscopic ablation of subserous myoma, and biopsy specimens of endometriosis were obtained from patients undergoing surgery for the diagnosis and treatment of endometriosis. Normal tissues of ovary, bladder, and rectum were obtained from these organs beside the lesions of endometriosis.

MAIN OUTCOME MEASURE(S)

Blood vessels were quantified according to the number of von Willebrand factor-positive endothelial cells. The VEGF and Flk-1 distribution were evaluated semiquantitatively by immunohistochemical staining.

RESULT(S)

More blood vessels were found in cases of endometriosis, particularly rectal endometriosis, compared with the respective control samples and with the eutopic endometrium, and they were localized in endometrial stroma around the glands. The VEGF and Flk-1 expression levels were also higher in cases of endometriosis, especially rectal endometriosis.

CONCLUSION(S)

Vascularization and VEGF and Flk-1 expression are significantly higher in deeply infiltrating endometriosis affecting the rectum, reinforcing the hypothesis that antiangiogenesis therapy may constitute a new modality of treatment, especially in cases of deep endometriosis involving the rectum.

Authors+Show Affiliations

Department of Histology and Embryology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17765237

Citation

Machado, Daniel Escorsim, et al. "Vascular Density and Distribution of Vascular Endothelial Growth Factor (VEGF) and Its Receptor VEGFR-2 (Flk-1) Are Significantly Higher in Patients With Deeply Infiltrating Endometriosis Affecting the Rectum." Fertility and Sterility, vol. 90, no. 1, 2008, pp. 148-55.
Machado DE, Abrao MS, Berardo PT, et al. Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum. Fertil Steril. 2008;90(1):148-55.
Machado, D. E., Abrao, M. S., Berardo, P. T., Takiya, C. M., & Nasciutti, L. E. (2008). Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum. Fertility and Sterility, 90(1), 148-55.
Machado DE, et al. Vascular Density and Distribution of Vascular Endothelial Growth Factor (VEGF) and Its Receptor VEGFR-2 (Flk-1) Are Significantly Higher in Patients With Deeply Infiltrating Endometriosis Affecting the Rectum. Fertil Steril. 2008;90(1):148-55. PubMed PMID: 17765237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum. AU - Machado,Daniel Escorsim, AU - Abrao,Maurício Simões, AU - Berardo,Plínio Tostes, AU - Takiya,Christina Maeda, AU - Nasciutti,Luiz Eurico, Y1 - 2007/09/04/ PY - 2006/09/30/received PY - 2007/05/24/revised PY - 2007/05/24/accepted PY - 2007/9/4/pubmed PY - 2008/7/18/medline PY - 2007/9/4/entrez SP - 148 EP - 55 JF - Fertility and sterility JO - Fertil. Steril. VL - 90 IS - 1 N2 - OBJECTIVE: To analyze vascular density and immunolocalization of angiogenic vascular endothelial growth factor (VEGF) and its receptor Flk-1 in the proliferative and secretory eutopic human endometrium and in three different sites of endometriosis: the ovary, bladder, and rectum. DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): Thirty women with endometriosis (10 ovarian, 10 bladder, 10 rectal) and 32 control women (10 proliferative endometrium, 10 secretory endometrium, 4 normal ovary, 4 normal bladder, 4 normal rectum). INTERVENTION(S): Normal endometrial samples were obtained from women during laparoscopic ablation of subserous myoma, and biopsy specimens of endometriosis were obtained from patients undergoing surgery for the diagnosis and treatment of endometriosis. Normal tissues of ovary, bladder, and rectum were obtained from these organs beside the lesions of endometriosis. MAIN OUTCOME MEASURE(S): Blood vessels were quantified according to the number of von Willebrand factor-positive endothelial cells. The VEGF and Flk-1 distribution were evaluated semiquantitatively by immunohistochemical staining. RESULT(S): More blood vessels were found in cases of endometriosis, particularly rectal endometriosis, compared with the respective control samples and with the eutopic endometrium, and they were localized in endometrial stroma around the glands. The VEGF and Flk-1 expression levels were also higher in cases of endometriosis, especially rectal endometriosis. CONCLUSION(S): Vascularization and VEGF and Flk-1 expression are significantly higher in deeply infiltrating endometriosis affecting the rectum, reinforcing the hypothesis that antiangiogenesis therapy may constitute a new modality of treatment, especially in cases of deep endometriosis involving the rectum. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17765237/Vascular_density_and_distribution_of_vascular_endothelial_growth_factor__VEGF__and_its_receptor_VEGFR_2__Flk_1__are_significantly_higher_in_patients_with_deeply_infiltrating_endometriosis_affecting_the_rectum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)01235-6 DB - PRIME DP - Unbound Medicine ER -