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Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 01; 32(1):145-9.PN

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is the most prevalent psychiatric disorder currently afflicting children and is among the most common chronic conditions affecting school-age children. Modafinil is structurally different from the psychostimulants that are typically used to treat ADHD and has been reported to be effective in improving the symptoms of ADHD. The aim of the present study was to further evaluate, under double blind and controlled conditions, the efficacy of modafinil for ADHD in children and adolescents as compared to methylphenidate. Patients included 60 outpatients, children (47 boys and 13 girls) between the ages of 6-15 who clearly met the DSM-IV-TR diagnostic criteria for ADHD. Subjects were recruited from an outpatient child and adolescent clinic for a 6 week double blind, randomized clinical trial. All study subjects were randomly assigned to receive either treatment with modafinil film coated tablet (in doses of 200-300 mg/day) depending on weight (200 mg/day for <30 kg and 300 mg/day for >30 kg) (group 1) or methylphenidate (in doses of 20-30 mg/day) depending on weight (20 mg/day for <30 kg and 30 mg/day for >30 kg) (group 2). The principal measure of outcome was the Teacher and Parent ADHD Rating Scale-IV. Patients were assessed at baseline and at 21 and 42 days after the medication started. No significant differences were observed between the two groups on the Parent and Teacher Rating Scale scores. Side effects of decreased appetite and difficulty falling asleep were observed more in the methylphenidate group. The results of this study indicate that modafinil significantly improved symptoms of ADHD and was well tolerated and it is beneficial in the treatment of children with ADHD.

Authors+Show Affiliations

Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran 13337, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17765380

Citation

Amiri, Shahrokh, et al. "Modafinil as a Treatment for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: a Double Blind, Randomized Clinical Trial." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 1, 2008, pp. 145-9.
Amiri S, Mohammadi MR, Mohammadi M, et al. Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):145-9.
Amiri, S., Mohammadi, M. R., Mohammadi, M., Nouroozinejad, G. H., Kahbazi, M., & Akhondzadeh, S. (2008). Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(1), 145-9.
Amiri S, et al. Modafinil as a Treatment for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: a Double Blind, Randomized Clinical Trial. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):145-9. PubMed PMID: 17765380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial. AU - Amiri,Shahrokh, AU - Mohammadi,Mohammad-Reza, AU - Mohammadi,Mohammad, AU - Nouroozinejad,Gholam-Hossein, AU - Kahbazi,Manijeh, AU - Akhondzadeh,Shahin, Y1 - 2007/08/08/ PY - 2007/04/14/received PY - 2007/07/29/revised PY - 2007/07/30/accepted PY - 2007/9/4/pubmed PY - 2008/5/3/medline PY - 2007/9/4/entrez SP - 145 EP - 9 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 1 N2 - Attention-Deficit/Hyperactivity Disorder (ADHD) is the most prevalent psychiatric disorder currently afflicting children and is among the most common chronic conditions affecting school-age children. Modafinil is structurally different from the psychostimulants that are typically used to treat ADHD and has been reported to be effective in improving the symptoms of ADHD. The aim of the present study was to further evaluate, under double blind and controlled conditions, the efficacy of modafinil for ADHD in children and adolescents as compared to methylphenidate. Patients included 60 outpatients, children (47 boys and 13 girls) between the ages of 6-15 who clearly met the DSM-IV-TR diagnostic criteria for ADHD. Subjects were recruited from an outpatient child and adolescent clinic for a 6 week double blind, randomized clinical trial. All study subjects were randomly assigned to receive either treatment with modafinil film coated tablet (in doses of 200-300 mg/day) depending on weight (200 mg/day for <30 kg and 300 mg/day for >30 kg) (group 1) or methylphenidate (in doses of 20-30 mg/day) depending on weight (20 mg/day for <30 kg and 30 mg/day for >30 kg) (group 2). The principal measure of outcome was the Teacher and Parent ADHD Rating Scale-IV. Patients were assessed at baseline and at 21 and 42 days after the medication started. No significant differences were observed between the two groups on the Parent and Teacher Rating Scale scores. Side effects of decreased appetite and difficulty falling asleep were observed more in the methylphenidate group. The results of this study indicate that modafinil significantly improved symptoms of ADHD and was well tolerated and it is beneficial in the treatment of children with ADHD. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17765380/Modafinil_as_a_treatment_for_Attention_Deficit/Hyperactivity_Disorder_in_children_and_adolescents:_a_double_blind_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00267-9 DB - PRIME DP - Unbound Medicine ER -