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Physical distress, emotional status, and quality of life in patients with nasopharyngeal cancer complicated by post-radiotherapy endocrinopathy.
Int J Radiat Oncol Biol Phys. 2008 Jan 01; 70(1):28-34.IJ

Abstract

PURPOSE

To explore factors affecting quality of life (QOL) among patients with nasopharyngeal cancer (NPC) complicated by post-radiotherapy endocrinopathy.

METHODS AND MATERIALS

This cross-sectional study was conducted in a tertiary medical center and involved a total of 43 post-radiotherapy, recurrence-free NPC patients with endocrinopathy. They performed self-assessment of their emotional status using the Beck Anxiety Inventory and Beck Depression Inventory-II, and their QoL with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire and the H&N35 cancer module.

RESULTS

Emotional and cognitive functioning of EORTC QLQ-C30 were the most affected. Fatigue, insomnia, and pain were the main concerns. Of the patients, 22 (51.2%) had anxiety and 19 (44.2%) had depression. Both depression and anxiety were negatively correlated with functional scales and global QoL but positively correlated with symptom scales. Multiple linear regression analysis revealed that physical distress symptoms of QLQ-C30 and physical functioning were the significant predictors of global QoL. Emotional and social functioning could predict depression, whereas emotional and physical functioning were significant predictors of anxiety.

CONCLUSIONS

NPC patients with post-radiotherapy endocrinopathy exhibit impaired cognitive function and negative emotions. Symptoms of physical distress play an important role in QoL perception. Measurement of EORTC QLQ-C30 can be a useful instrument for the early detection of patients' impaired cognitive function and psychological morbidity. The high psychological distress related to the endocrine disturbances or the impact of NPC itself needs further study.

Authors+Show Affiliations

Department of Family Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17765405

Citation

Lue, Bee-Horng, et al. "Physical Distress, Emotional Status, and Quality of Life in Patients With Nasopharyngeal Cancer Complicated By Post-radiotherapy Endocrinopathy." International Journal of Radiation Oncology, Biology, Physics, vol. 70, no. 1, 2008, pp. 28-34.
Lue BH, Huang TS, Chen HJ. Physical distress, emotional status, and quality of life in patients with nasopharyngeal cancer complicated by post-radiotherapy endocrinopathy. Int J Radiat Oncol Biol Phys. 2008;70(1):28-34.
Lue, B. H., Huang, T. S., & Chen, H. J. (2008). Physical distress, emotional status, and quality of life in patients with nasopharyngeal cancer complicated by post-radiotherapy endocrinopathy. International Journal of Radiation Oncology, Biology, Physics, 70(1), 28-34.
Lue BH, Huang TS, Chen HJ. Physical Distress, Emotional Status, and Quality of Life in Patients With Nasopharyngeal Cancer Complicated By Post-radiotherapy Endocrinopathy. Int J Radiat Oncol Biol Phys. 2008 Jan 1;70(1):28-34. PubMed PMID: 17765405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical distress, emotional status, and quality of life in patients with nasopharyngeal cancer complicated by post-radiotherapy endocrinopathy. AU - Lue,Bee-Horng, AU - Huang,Tien-Shang, AU - Chen,Hsiu-Jung, Y1 - 2007/08/31/ PY - 2006/09/28/received PY - 2007/06/07/revised PY - 2007/06/07/accepted PY - 2007/9/4/pubmed PY - 2008/2/8/medline PY - 2007/9/4/entrez SP - 28 EP - 34 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 70 IS - 1 N2 - PURPOSE: To explore factors affecting quality of life (QOL) among patients with nasopharyngeal cancer (NPC) complicated by post-radiotherapy endocrinopathy. METHODS AND MATERIALS: This cross-sectional study was conducted in a tertiary medical center and involved a total of 43 post-radiotherapy, recurrence-free NPC patients with endocrinopathy. They performed self-assessment of their emotional status using the Beck Anxiety Inventory and Beck Depression Inventory-II, and their QoL with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire and the H&N35 cancer module. RESULTS: Emotional and cognitive functioning of EORTC QLQ-C30 were the most affected. Fatigue, insomnia, and pain were the main concerns. Of the patients, 22 (51.2%) had anxiety and 19 (44.2%) had depression. Both depression and anxiety were negatively correlated with functional scales and global QoL but positively correlated with symptom scales. Multiple linear regression analysis revealed that physical distress symptoms of QLQ-C30 and physical functioning were the significant predictors of global QoL. Emotional and social functioning could predict depression, whereas emotional and physical functioning were significant predictors of anxiety. CONCLUSIONS: NPC patients with post-radiotherapy endocrinopathy exhibit impaired cognitive function and negative emotions. Symptoms of physical distress play an important role in QoL perception. Measurement of EORTC QLQ-C30 can be a useful instrument for the early detection of patients' impaired cognitive function and psychological morbidity. The high psychological distress related to the endocrine disturbances or the impact of NPC itself needs further study. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/17765405/Physical_distress_emotional_status_and_quality_of_life_in_patients_with_nasopharyngeal_cancer_complicated_by_post_radiotherapy_endocrinopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(07)01169-8 DB - PRIME DP - Unbound Medicine ER -