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Plasma urocortin levels in the diagnosis of ovarian endometriosis.
Obstet Gynecol. 2007 Sep; 110(3):594-600.OG

Abstract

OBJECTIVE

Urocortin is a neuropeptide, member of the corticotropin-releasing hormone family, that is produced by the human endometrium. Ovarian endometrioma is a prevalent gynecologic disorder still lacking specific serum markers. In the present study we measured systemic levels of urocortin to assess the diagnostic performance of its determination in distinguishing endometriomas from other benign ovarian cysts.

METHODS

Plasma urocortin was measured by radioimmunoassay in women with ovarian endometrioma (n=40) and in women with benign, nonendometriotic ovarian cysts (n=40). The diagnostic accuracy of urocortin measurement was evaluated by receiver operating characteristic curve and compared with the standard marker, CA 125. To support the local origin of the peptide, we also evaluated its localization in endometriomas by immunohistochemistry and its concentrations in cyst fluid and peritoneal fluid of 12 women with endometrioma.

RESULTS

Plasma urocortin levels were twice as high in women with endometrioma (median 49 pg/mL, interquartile range 41-63 pg/mL) than in the control group (19 [15-23] pg/mL, P<.001) and significantly higher in the cystic content of endometriomas than in the peritoneal fluid and plasma (P<.05). The peptide was immunolocalized in endometrioma glands and stromal capillary vessels. Elevated plasma urocortin levels detected 88% of the cases of endometrioma with 90% specificity, whereas CA 125 detected only 65% of the cases with the same specificity.

CONCLUSION

Plasma urocortin is increased in women with endometriomas, and its measurement may be useful for the differential diagnosis of endometrioma compared with other benign ovarian cysts.

LEVEL OF EVIDENCE

II.

Authors+Show Affiliations

Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetrics and Gynecology, University of Siena, Siena, Italy. florio@unisi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17766605

Citation

Florio, Pasquale, et al. "Plasma Urocortin Levels in the Diagnosis of Ovarian Endometriosis." Obstetrics and Gynecology, vol. 110, no. 3, 2007, pp. 594-600.
Florio P, Reis FM, Torres PB, et al. Plasma urocortin levels in the diagnosis of ovarian endometriosis. Obstet Gynecol. 2007;110(3):594-600.
Florio, P., Reis, F. M., Torres, P. B., Calonaci, F., Toti, P., Bocchi, C., Linton, E. A., & Petraglia, F. (2007). Plasma urocortin levels in the diagnosis of ovarian endometriosis. Obstetrics and Gynecology, 110(3), 594-600.
Florio P, et al. Plasma Urocortin Levels in the Diagnosis of Ovarian Endometriosis. Obstet Gynecol. 2007;110(3):594-600. PubMed PMID: 17766605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma urocortin levels in the diagnosis of ovarian endometriosis. AU - Florio,Pasquale, AU - Reis,Fernando M, AU - Torres,Paulo B, AU - Calonaci,Francesco, AU - Toti,Paolo, AU - Bocchi,Caterina, AU - Linton,Elizabeth A, AU - Petraglia,Felice, PY - 2007/9/4/pubmed PY - 2007/10/3/medline PY - 2007/9/4/entrez SP - 594 EP - 600 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 110 IS - 3 N2 - OBJECTIVE: Urocortin is a neuropeptide, member of the corticotropin-releasing hormone family, that is produced by the human endometrium. Ovarian endometrioma is a prevalent gynecologic disorder still lacking specific serum markers. In the present study we measured systemic levels of urocortin to assess the diagnostic performance of its determination in distinguishing endometriomas from other benign ovarian cysts. METHODS: Plasma urocortin was measured by radioimmunoassay in women with ovarian endometrioma (n=40) and in women with benign, nonendometriotic ovarian cysts (n=40). The diagnostic accuracy of urocortin measurement was evaluated by receiver operating characteristic curve and compared with the standard marker, CA 125. To support the local origin of the peptide, we also evaluated its localization in endometriomas by immunohistochemistry and its concentrations in cyst fluid and peritoneal fluid of 12 women with endometrioma. RESULTS: Plasma urocortin levels were twice as high in women with endometrioma (median 49 pg/mL, interquartile range 41-63 pg/mL) than in the control group (19 [15-23] pg/mL, P<.001) and significantly higher in the cystic content of endometriomas than in the peritoneal fluid and plasma (P<.05). The peptide was immunolocalized in endometrioma glands and stromal capillary vessels. Elevated plasma urocortin levels detected 88% of the cases of endometrioma with 90% specificity, whereas CA 125 detected only 65% of the cases with the same specificity. CONCLUSION: Plasma urocortin is increased in women with endometriomas, and its measurement may be useful for the differential diagnosis of endometrioma compared with other benign ovarian cysts. LEVEL OF EVIDENCE: II. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/17766605/Plasma_urocortin_levels_in_the_diagnosis_of_ovarian_endometriosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=17766605.ui DB - PRIME DP - Unbound Medicine ER -