Tags

Type your tag names separated by a space and hit enter

A severe outbreak of contagious ecthyma (orf) in a free-ranging musk ox (Ovibos moschatus) population in Norway.
Vet Microbiol 2008; 127(1-2):10-20VM

Abstract

During July-October 2004, 19 (18 calves, 1 yearling) free-ranging musk oxen (Ovibos moschatus) at Dovre, Norway, were observed with contagious echtyma-like lesions, and 16 of them were euthanized. Six musk oxen were subjected to necropsy, histopathological and microbiological examinations. All euthanized animals had lesions consistent with contagious ecthyma presenting as wart-like, scabby lesions on the muzzle, lips, oral mucosa and limbs to a variable extent. The histopathological examination showed pustular dermatitis characterized by epidermal proliferation, reticular degeneration, degenerating keratinocytes with intracytoplasmic eosinophilic inclusion bodies, vesicopustules, microabscesses and multifocal ulcerations in the epidermis which was covered by a serocellular crust. Pathology and bacteriology showed evidence of secondary infections in the skin and draining lymph nodes. Electron microscopy (negative staining) of lesions from four animals detected parapoxvirus with the typical arrangement of the outer protein filaments. Parapoxvirus DNA was detected in tissue samples from two examined animals by polymerase chain reaction (PCR) with primers from the B2L-gene. A DNA sequence of 326 nucleotides from the amplicon was compared with similar DNA sequences from parapoxvirus isolated from sheep, reindeer, musk ox and cattle. The outbreak was caused by a virus similar to other circulating orf virus variants in Norway. Antibodies against parapoxvirus were detected with a virus neutralization test in 3 of 35 musk oxen (8.6%) sampled at Dovre between 2004 and 2006. This is the first report of a severe outbreak of contagious ecthyma in free-ranging musk oxen.

Authors+Show Affiliations

National Veterinary Institute, Section for Wildlife Diseases, Oslo, Norway. turid.vikoren@vetinst.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17768017

Citation

Vikøren, Turid, et al. "A Severe Outbreak of Contagious Ecthyma (orf) in a Free-ranging Musk Ox (Ovibos Moschatus) Population in Norway." Veterinary Microbiology, vol. 127, no. 1-2, 2008, pp. 10-20.
Vikøren T, Lillehaug A, Akerstedt J, et al. A severe outbreak of contagious ecthyma (orf) in a free-ranging musk ox (Ovibos moschatus) population in Norway. Vet Microbiol. 2008;127(1-2):10-20.
Vikøren, T., Lillehaug, A., Akerstedt, J., Bretten, T., Haugum, M., & Tryland, M. (2008). A severe outbreak of contagious ecthyma (orf) in a free-ranging musk ox (Ovibos moschatus) population in Norway. Veterinary Microbiology, 127(1-2), pp. 10-20.
Vikøren T, et al. A Severe Outbreak of Contagious Ecthyma (orf) in a Free-ranging Musk Ox (Ovibos Moschatus) Population in Norway. Vet Microbiol. 2008 Feb 5;127(1-2):10-20. PubMed PMID: 17768017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A severe outbreak of contagious ecthyma (orf) in a free-ranging musk ox (Ovibos moschatus) population in Norway. AU - Vikøren,Turid, AU - Lillehaug,Atle, AU - Akerstedt,Johan, AU - Bretten,Tord, AU - Haugum,Magne, AU - Tryland,Morten, Y1 - 2007/08/02/ PY - 2007/05/11/received PY - 2007/07/23/revised PY - 2007/07/24/accepted PY - 2007/9/5/pubmed PY - 2008/11/6/medline PY - 2007/9/5/entrez SP - 10 EP - 20 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 127 IS - 1-2 N2 - During July-October 2004, 19 (18 calves, 1 yearling) free-ranging musk oxen (Ovibos moschatus) at Dovre, Norway, were observed with contagious echtyma-like lesions, and 16 of them were euthanized. Six musk oxen were subjected to necropsy, histopathological and microbiological examinations. All euthanized animals had lesions consistent with contagious ecthyma presenting as wart-like, scabby lesions on the muzzle, lips, oral mucosa and limbs to a variable extent. The histopathological examination showed pustular dermatitis characterized by epidermal proliferation, reticular degeneration, degenerating keratinocytes with intracytoplasmic eosinophilic inclusion bodies, vesicopustules, microabscesses and multifocal ulcerations in the epidermis which was covered by a serocellular crust. Pathology and bacteriology showed evidence of secondary infections in the skin and draining lymph nodes. Electron microscopy (negative staining) of lesions from four animals detected parapoxvirus with the typical arrangement of the outer protein filaments. Parapoxvirus DNA was detected in tissue samples from two examined animals by polymerase chain reaction (PCR) with primers from the B2L-gene. A DNA sequence of 326 nucleotides from the amplicon was compared with similar DNA sequences from parapoxvirus isolated from sheep, reindeer, musk ox and cattle. The outbreak was caused by a virus similar to other circulating orf virus variants in Norway. Antibodies against parapoxvirus were detected with a virus neutralization test in 3 of 35 musk oxen (8.6%) sampled at Dovre between 2004 and 2006. This is the first report of a severe outbreak of contagious ecthyma in free-ranging musk oxen. SN - 0378-1135 UR - https://www.unboundmedicine.com/medline/citation/17768017/A_severe_outbreak_of_contagious_ecthyma__orf__in_a_free_ranging_musk_ox__Ovibos_moschatus__population_in_Norway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(07)00368-9 DB - PRIME DP - Unbound Medicine ER -