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Risk factors for clinical fractures among postmenopausal women: a 10-year prospective study.
Menopause Int. 2007 Sep; 13(3):110-5.MI

Abstract

OBJECTIVE

Only scarce data are available on the long-term absolute risk (AR) of all clinical fractures, taking into account the time when they occurred. Therefore, we assessed during a 10-year follow-up the risk factors associated with the occurrence of any first or second clinical fracture.

STUDY DESIGN

This was a population-based study in 10 general practice centres. The sample comprised 2372 postmenopausal women, aged between 50 and 80 years at baseline, who completed a questionnaire about the incidence of radiographically confirmed fractures and fracture risks, analysed by multiple Cox regression.

MAIN OUTCOME MEASURE

AR for any clinical fracture.

RESULTS

During the 10-year follow-up, 380 women (16%) had a fracture. A first fracture occurred in 267 women (11%). Osteoporosis at the lumbar spine (T-score <-2.5; hazard ratio (HR) 1.8, 95% confidence interval (CI) 1.4-2.3) and age over 60 years (HR1.4, 95% CI 1.1-1.8) were the only risk factors retained in the Cox analysis. The AR in the lowest-risk group was 10%, and it was 23% in the highest-risk group. A second fracture occurred in 113 women during follow-up (5%). The time when a fracture occurred was the only risk factor retained in the Cox analysis. The AR for a second fracture was 41% in the five years after any first fracture before baseline and 25% if the first fracture had occurred earlier (HR 1.8, 95% CI 1.3-2.7).

CONCLUSION

In postmenopausal women, over a 10-year follow-up, the AR of a second clinical fracture is highest in the five years after any first clinical fracture. The AR for a first clinical fracture is lower and depends on osteoporosis and age.

Authors+Show Affiliations

Department of General Practice, Maastricht University, The Netherlands. t.vangeel@hag.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17785036

Citation

van Geel, Tineke A C M., et al. "Risk Factors for Clinical Fractures Among Postmenopausal Women: a 10-year Prospective Study." Menopause International, vol. 13, no. 3, 2007, pp. 110-5.
van Geel TA, Geusens PP, Nagtzaam IF, et al. Risk factors for clinical fractures among postmenopausal women: a 10-year prospective study. Menopause Int. 2007;13(3):110-5.
van Geel, T. A., Geusens, P. P., Nagtzaam, I. F., van der Voort, D. J., Schreurs, C. M., Rinkens, P. E., & Dinant, G. J. (2007). Risk factors for clinical fractures among postmenopausal women: a 10-year prospective study. Menopause International, 13(3), 110-5.
van Geel TA, et al. Risk Factors for Clinical Fractures Among Postmenopausal Women: a 10-year Prospective Study. Menopause Int. 2007;13(3):110-5. PubMed PMID: 17785036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for clinical fractures among postmenopausal women: a 10-year prospective study. AU - van Geel,Tineke A C M, AU - Geusens,Piet P, AU - Nagtzaam,Ivo F, AU - van der Voort,Danny J M, AU - Schreurs,Cyril M J R, AU - Rinkens,Paula E L M, AU - Dinant,Geert-Jan, PY - 2007/9/6/pubmed PY - 2007/12/19/medline PY - 2007/9/6/entrez SP - 110 EP - 5 JF - Menopause international JO - Menopause Int VL - 13 IS - 3 N2 - OBJECTIVE: Only scarce data are available on the long-term absolute risk (AR) of all clinical fractures, taking into account the time when they occurred. Therefore, we assessed during a 10-year follow-up the risk factors associated with the occurrence of any first or second clinical fracture. STUDY DESIGN: This was a population-based study in 10 general practice centres. The sample comprised 2372 postmenopausal women, aged between 50 and 80 years at baseline, who completed a questionnaire about the incidence of radiographically confirmed fractures and fracture risks, analysed by multiple Cox regression. MAIN OUTCOME MEASURE: AR for any clinical fracture. RESULTS: During the 10-year follow-up, 380 women (16%) had a fracture. A first fracture occurred in 267 women (11%). Osteoporosis at the lumbar spine (T-score <-2.5; hazard ratio (HR) 1.8, 95% confidence interval (CI) 1.4-2.3) and age over 60 years (HR1.4, 95% CI 1.1-1.8) were the only risk factors retained in the Cox analysis. The AR in the lowest-risk group was 10%, and it was 23% in the highest-risk group. A second fracture occurred in 113 women during follow-up (5%). The time when a fracture occurred was the only risk factor retained in the Cox analysis. The AR for a second fracture was 41% in the five years after any first fracture before baseline and 25% if the first fracture had occurred earlier (HR 1.8, 95% CI 1.3-2.7). CONCLUSION: In postmenopausal women, over a 10-year follow-up, the AR of a second clinical fracture is highest in the five years after any first clinical fracture. The AR for a first clinical fracture is lower and depends on osteoporosis and age. SN - 1754-0453 UR - https://www.unboundmedicine.com/medline/citation/17785036/Risk_factors_for_clinical_fractures_among_postmenopausal_women:_a_10_year_prospective_study_ L2 - https://medlineplus.gov/womenshealth.html DB - PRIME DP - Unbound Medicine ER -