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A new line immunoassay for the multiparametric detection of antiganglioside autoantibodies in patients with autoimmune peripheral neuropathies.
Ann N Y Acad Sci. 2007 Aug; 1109:256-64.AN

Abstract

A novel line immunoassay for the multiparametric detection of 11 antiganglioside autoantibodies (GM1, GM2, GM3, GM4, GD1a, GD1b, GD2, GD3, GT1a, GT1b, and GQ1b) was evaluated by comparing the reactivities in sera of 77 patients with suspected or definite autoimmune peripheral neuropathies (PNP), 60 blood donors, and 30 systemic lupus erythematodes (SLE) patients. At least one antiganglioside autoantibody was detectable in 97.4% of the patients with neuropathies compared to 12.2% in the control group. A broad spectrum of reactivities with more than two antiganglioside autoantibodies including all tested gangliosides except GD2 and GT1b was found in nearly one-third of the patients with neuropathies whereas in the control group autoantibody profiles with more than two reactivities were observed in two SLE patients only. For the first time anti-GM4 IgG and IgM antibodies were shown in PNP including Guillain-Barré syndrome (GBS), Miller-Fisher syndrome (MFS), and multifocal motor neuropathy (MMN). Different autoantibody profiles detectable by this multiparametric assay may help to diagnose different entities within the growing spectrum of autoimmune PNP.

Authors+Show Affiliations

Institute of Immunology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. k_conrad@mail.zih.tu-dresden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17785314

Citation

Conrad, Karsten, et al. "A New Line Immunoassay for the Multiparametric Detection of Antiganglioside Autoantibodies in Patients With Autoimmune Peripheral Neuropathies." Annals of the New York Academy of Sciences, vol. 1109, 2007, pp. 256-64.
Conrad K, Schneider H, Ziemssen T, et al. A new line immunoassay for the multiparametric detection of antiganglioside autoantibodies in patients with autoimmune peripheral neuropathies. Ann N Y Acad Sci. 2007;1109:256-64.
Conrad, K., Schneider, H., Ziemssen, T., Talaska, T., Reinhold, D., Humbel, R. L., & Roggenbuck, D. (2007). A new line immunoassay for the multiparametric detection of antiganglioside autoantibodies in patients with autoimmune peripheral neuropathies. Annals of the New York Academy of Sciences, 1109, 256-64.
Conrad K, et al. A New Line Immunoassay for the Multiparametric Detection of Antiganglioside Autoantibodies in Patients With Autoimmune Peripheral Neuropathies. Ann N Y Acad Sci. 2007;1109:256-64. PubMed PMID: 17785314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new line immunoassay for the multiparametric detection of antiganglioside autoantibodies in patients with autoimmune peripheral neuropathies. AU - Conrad,Karsten, AU - Schneider,Hauke, AU - Ziemssen,Tjalf, AU - Talaska,Thomas, AU - Reinhold,Dirk, AU - Humbel,Rene-Louis, AU - Roggenbuck,Dirk, PY - 2007/9/6/pubmed PY - 2007/10/3/medline PY - 2007/9/6/entrez SP - 256 EP - 64 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1109 N2 - A novel line immunoassay for the multiparametric detection of 11 antiganglioside autoantibodies (GM1, GM2, GM3, GM4, GD1a, GD1b, GD2, GD3, GT1a, GT1b, and GQ1b) was evaluated by comparing the reactivities in sera of 77 patients with suspected or definite autoimmune peripheral neuropathies (PNP), 60 blood donors, and 30 systemic lupus erythematodes (SLE) patients. At least one antiganglioside autoantibody was detectable in 97.4% of the patients with neuropathies compared to 12.2% in the control group. A broad spectrum of reactivities with more than two antiganglioside autoantibodies including all tested gangliosides except GD2 and GT1b was found in nearly one-third of the patients with neuropathies whereas in the control group autoantibody profiles with more than two reactivities were observed in two SLE patients only. For the first time anti-GM4 IgG and IgM antibodies were shown in PNP including Guillain-Barré syndrome (GBS), Miller-Fisher syndrome (MFS), and multifocal motor neuropathy (MMN). Different autoantibody profiles detectable by this multiparametric assay may help to diagnose different entities within the growing spectrum of autoimmune PNP. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17785314/A_new_line_immunoassay_for_the_multiparametric_detection_of_antiganglioside_autoantibodies_in_patients_with_autoimmune_peripheral_neuropathies_ L2 - https://doi.org/10.1196/annals.1398.031 DB - PRIME DP - Unbound Medicine ER -