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Fingolimod: a novel immunosuppressant for multiple sclerosis.
Ann Pharmacother. 2007 Oct; 41(10):1660-8.AP

Abstract

OBJECTIVE

To review the pharmacology, pharmacokinetics, efficacy, and safety of fingolimod, a novel immune modulator.

DATA SOURCES

Information was obtained through a MEDLINE search (1966-February 2007) and from published abstracts. Search terms included fingolimod, FTY720, FTY-720, and sphingosine-1-phosphate receptor agonist.

STUDY SELECTION AND DATA EXTRACTION

All English-language studies and abstracts pertaining to fingolimod were considered for inclusion. Preference was given to human data.

DATA SYNTHESIS

Fingolimod is the first in a new class of immune modulators known as the sphingosine-1-phosphate receptor agonists. It is administered orally once daily and causes a dose-related reduction in the number of circulating lymphocytes by preventing their egress from secondary lymph organs, but it does not alter T-cell activation or proliferation. Bradycardia and lymphopenia are the most common adverse effects. Clinical trials have evaluated the efficacy of fingolimod in renal transplantation and multiple sclerosis (MS). Further research for renal transplantation will not take place, but Phase 3 studies in MS are underway, as Phase 2 study results are favorable.

CONCLUSIONS

Due to its distinct mechanism of action and its oral administration, fingolimod may be a useful therapeutic option for patients with relapsing forms of MS. More data are needed to assess the safety and clinical utility of fingolimod.

Authors+Show Affiliations

Partners Multiple Sclerosis Center, Brookline, MA 02445, USA. bbrown8@partners.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17785617

Citation

Brown, Brandon A., et al. "Fingolimod: a Novel Immunosuppressant for Multiple Sclerosis." The Annals of Pharmacotherapy, vol. 41, no. 10, 2007, pp. 1660-8.
Brown BA, Kantesaria PP, McDevitt LM. Fingolimod: a novel immunosuppressant for multiple sclerosis. Ann Pharmacother. 2007;41(10):1660-8.
Brown, B. A., Kantesaria, P. P., & McDevitt, L. M. (2007). Fingolimod: a novel immunosuppressant for multiple sclerosis. The Annals of Pharmacotherapy, 41(10), 1660-8.
Brown BA, Kantesaria PP, McDevitt LM. Fingolimod: a Novel Immunosuppressant for Multiple Sclerosis. Ann Pharmacother. 2007;41(10):1660-8. PubMed PMID: 17785617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fingolimod: a novel immunosuppressant for multiple sclerosis. AU - Brown,Brandon A, AU - Kantesaria,Pranish P, AU - McDevitt,Lisa M, Y1 - 2007/09/04/ PY - 2007/9/6/pubmed PY - 2007/11/9/medline PY - 2007/9/6/entrez SP - 1660 EP - 8 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 41 IS - 10 N2 - OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of fingolimod, a novel immune modulator. DATA SOURCES: Information was obtained through a MEDLINE search (1966-February 2007) and from published abstracts. Search terms included fingolimod, FTY720, FTY-720, and sphingosine-1-phosphate receptor agonist. STUDY SELECTION AND DATA EXTRACTION: All English-language studies and abstracts pertaining to fingolimod were considered for inclusion. Preference was given to human data. DATA SYNTHESIS: Fingolimod is the first in a new class of immune modulators known as the sphingosine-1-phosphate receptor agonists. It is administered orally once daily and causes a dose-related reduction in the number of circulating lymphocytes by preventing their egress from secondary lymph organs, but it does not alter T-cell activation or proliferation. Bradycardia and lymphopenia are the most common adverse effects. Clinical trials have evaluated the efficacy of fingolimod in renal transplantation and multiple sclerosis (MS). Further research for renal transplantation will not take place, but Phase 3 studies in MS are underway, as Phase 2 study results are favorable. CONCLUSIONS: Due to its distinct mechanism of action and its oral administration, fingolimod may be a useful therapeutic option for patients with relapsing forms of MS. More data are needed to assess the safety and clinical utility of fingolimod. SN - 1542-6270 UR - https://www.unboundmedicine.com/medline/citation/17785617/Fingolimod:_a_novel_immunosuppressant_for_multiple_sclerosis_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1G424?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -