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Combination of microdialysis and Glucosensor permits continuous (on line) s.c. glucose monitoring in a patient operated device: I. In vitro evaluation.

Abstract

A device for continuous glucose monitoring in fluids was obtained by combining the microdialysis technique with a measuring flow chamber of the "Glucosensor Unitec Ulm" using the GOD method for determining amperometrically blood glucose profiles. The in vitro experiments demonstrate that the relative recovery of glucose by this device is inversely related to the flow rate of the microdialysis perfusion fluid, which, in turn, is inversely related to the response time of the device. The glucose signal increases linearly with the area of the microdialysis working membrane (r = 0.98), and with the glucose concentrations of the standard solutions (r greater than 0.95). The variation coefficient for repeated measurements is below 8%. The accuracy of the device as demonstrated by mean measuring deviation ranges between 1 and 3.8%.

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  • Authors

    , , , ,

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    MeSH

    Biosensing Techniques
    Blood Glucose Self-Monitoring
    Dialysis
    Evaluation Studies as Topic
    Glucose Oxidase
    Humans

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1778599

    Citation

    TY - JOUR T1 - Combination of microdialysis and Glucosensor permits continuous (on line) s.c. glucose monitoring in a patient operated device: I. In vitro evaluation. AU - Keck,F S, AU - Kerner,W, AU - Meyerhoff,C, AU - Zier,H, AU - Pfeiffer,E F, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 617 EP - 8 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme JO - Horm. Metab. Res. VL - 23 IS - 12 N2 - A device for continuous glucose monitoring in fluids was obtained by combining the microdialysis technique with a measuring flow chamber of the "Glucosensor Unitec Ulm" using the GOD method for determining amperometrically blood glucose profiles. The in vitro experiments demonstrate that the relative recovery of glucose by this device is inversely related to the flow rate of the microdialysis perfusion fluid, which, in turn, is inversely related to the response time of the device. The glucose signal increases linearly with the area of the microdialysis working membrane (r = 0.98), and with the glucose concentrations of the standard solutions (r greater than 0.95). The variation coefficient for repeated measurements is below 8%. The accuracy of the device as demonstrated by mean measuring deviation ranges between 1 and 3.8%. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/1778599/abstract/Combination_of_microdialysis_and_Glucosensor_permits_continuous__on_line__s_c__glucose_monitoring_in_a_patient_operated_device:_I__In_vitro_evaluation_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1003769 ER -