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Markers of bone metabolism in eugonadal female patients with beta-thalassemia major.
Pediatr Hematol Oncol 2007 Oct-Nov; 24(7):481-91PH

Abstract

Osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) have been recently implicated in the pathogenesis of various types of osteoporosis. The aim of this study was to investigate bone turnover in eugonadal female patients with this disease and characterize the possible role of the OPG/RANKL system in thalassemia-related bone loss. Markers of bone turnover and bone mineral density (BMD) were measured in 16 eugonadal young females with beta-thalassemia major and 18 age- and sex-matched healthy controls. Bone turnover was significantly increased in thalassemic patients compared to controls but OPG was significantly higher in healthy subjects. BMD values negatively correlated with urine markers of bone resorption but not with OPG/sRANKL system.

Authors+Show Affiliations

Endocrine Department, Hippokrateion Hospital of Athens, Athens, Greece. drangelnick@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17786784

Citation

Angelopoulos, Nicholas G., et al. "Markers of Bone Metabolism in Eugonadal Female Patients With Beta-thalassemia Major." Pediatric Hematology and Oncology, vol. 24, no. 7, 2007, pp. 481-91.
Angelopoulos NG, Goula A, Katounda E, et al. Markers of bone metabolism in eugonadal female patients with beta-thalassemia major. Pediatr Hematol Oncol. 2007;24(7):481-91.
Angelopoulos, N. G., Goula, A., Katounda, E., Rombopoulos, G., Kaltzidou, V., Kaltsas, D., ... Tolis, G. (2007). Markers of bone metabolism in eugonadal female patients with beta-thalassemia major. Pediatric Hematology and Oncology, 24(7), pp. 481-91.
Angelopoulos NG, et al. Markers of Bone Metabolism in Eugonadal Female Patients With Beta-thalassemia Major. Pediatr Hematol Oncol. 2007;24(7):481-91. PubMed PMID: 17786784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of bone metabolism in eugonadal female patients with beta-thalassemia major. AU - Angelopoulos,Nicholas G, AU - Goula,Anastasia, AU - Katounda,Eugenia, AU - Rombopoulos,Grigorios, AU - Kaltzidou,Victoria, AU - Kaltsas,Dimitrios, AU - Konstandelou,Evangellia, AU - Tolis,George, PY - 2007/9/6/pubmed PY - 2007/10/17/medline PY - 2007/9/6/entrez SP - 481 EP - 91 JF - Pediatric hematology and oncology JO - Pediatr Hematol Oncol VL - 24 IS - 7 N2 - Osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) have been recently implicated in the pathogenesis of various types of osteoporosis. The aim of this study was to investigate bone turnover in eugonadal female patients with this disease and characterize the possible role of the OPG/RANKL system in thalassemia-related bone loss. Markers of bone turnover and bone mineral density (BMD) were measured in 16 eugonadal young females with beta-thalassemia major and 18 age- and sex-matched healthy controls. Bone turnover was significantly increased in thalassemic patients compared to controls but OPG was significantly higher in healthy subjects. BMD values negatively correlated with urine markers of bone resorption but not with OPG/sRANKL system. SN - 1521-0669 UR - https://www.unboundmedicine.com/medline/citation/17786784/Markers_of_bone_metabolism_in_eugonadal_female_patients_with_beta_thalassemia_major_ L2 - http://www.tandfonline.com/doi/full/10.1080/08880010701533611 DB - PRIME DP - Unbound Medicine ER -