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Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases.
J Neurol Sci. 1991 Nov; 106(1):50-5.JN

Abstract

The binding of the selective 5-HT2 antagonist [3H]ketanserin has been investigated in the temporal cortex of patients with Alzheimer's disease (SDAT), Parkinson's disease (PD), senile dementia of Lewy body type (SDLT) and neuropathologically normal subjects (control). 5-HT2 binding was reduced in SDAT, PD with dementia and SDLT. SDAT showed a 5-HT2 receptor deficit across most of the cortical layers. A significant decrease in 5-HT2 binding in the deep cortical layers was found in those SDLT cases without hallucinations. SDLT cases with hallucinations only showed a deficit in one upper layer. There was a significant difference in cortical layers III and V between SDLT without hallucinations and SDLT with hallucinations. The results confirm an abnormality of serotonin binding in various forms of dementia and suggest that preservation of 5-HT2 receptor in the temporal cortex may differentiate hallucinating from non-hallucinating cases of SDLT.

Authors+Show Affiliations

Cheng AV
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, U.K.
Ferrier IN
No affiliation info available
Morris CM
No affiliation info available
Jabeen S
No affiliation info available
Sahgal A
No affiliation info available
McKeith IG
No affiliation info available
Edwardson JA
No affiliation info available
Perry RH
No affiliation info available
Perry EK
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseDementiaHallucinationsHumansKetanserinLewy BodiesMiddle AgedParkinson DiseaseReceptors, SerotoninSerotoninTemporal Lobe

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1779239

Citation

Cheng, A V., et al. "Cortical serotonin-S2 Receptor Binding in Lewy Body Dementia, Alzheimer's and Parkinson's Diseases." Journal of the Neurological Sciences, vol. 106, no. 1, 1991, pp. 50-5.
Cheng AV, Ferrier IN, Morris CM, et al. Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases. J Neurol Sci. 1991;106(1):50-5.
Cheng, A. V., Ferrier, I. N., Morris, C. M., Jabeen, S., Sahgal, A., McKeith, I. G., Edwardson, J. A., Perry, R. H., & Perry, E. K. (1991). Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases. Journal of the Neurological Sciences, 106(1), 50-5.
Cheng AV, et al. Cortical serotonin-S2 Receptor Binding in Lewy Body Dementia, Alzheimer's and Parkinson's Diseases. J Neurol Sci. 1991;106(1):50-5. PubMed PMID: 1779239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases. AU - Cheng,A V, AU - Ferrier,I N, AU - Morris,C M, AU - Jabeen,S, AU - Sahgal,A, AU - McKeith,I G, AU - Edwardson,J A, AU - Perry,R H, AU - Perry,E K, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 50 EP - 5 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 106 IS - 1 N2 - The binding of the selective 5-HT2 antagonist [3H]ketanserin has been investigated in the temporal cortex of patients with Alzheimer's disease (SDAT), Parkinson's disease (PD), senile dementia of Lewy body type (SDLT) and neuropathologically normal subjects (control). 5-HT2 binding was reduced in SDAT, PD with dementia and SDLT. SDAT showed a 5-HT2 receptor deficit across most of the cortical layers. A significant decrease in 5-HT2 binding in the deep cortical layers was found in those SDLT cases without hallucinations. SDLT cases with hallucinations only showed a deficit in one upper layer. There was a significant difference in cortical layers III and V between SDLT without hallucinations and SDLT with hallucinations. The results confirm an abnormality of serotonin binding in various forms of dementia and suggest that preservation of 5-HT2 receptor in the temporal cortex may differentiate hallucinating from non-hallucinating cases of SDLT. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/1779239/Cortical_serotonin_S2_receptor_binding_in_Lewy_body_dementia_Alzheimer's_and_Parkinson's_diseases_ DB - PRIME DP - Unbound Medicine ER -