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Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis?
Thromb Res 2008; 121(6):743-50TR

Abstract

INTRODUCTION

Whether thrombophilic disorders, which are established risk factors for venous thromboembolism (VTE), also increase the risk of arterial thrombosis is still unknown.

MATERIALS AND METHODS

We analyzed data from 1081 consecutive patients (649 F/432 M, 16-93 years of age) with previous VTE registered in the MAISTHRO (MAin-ISar-THROmbosis) database with regard to arterial thrombotic events and contributing risk factors. Screening for thrombophilia included testing for factor V Leiden and prothrombin G20210A mutation, antiphospholipid antibodies and activities of factor VIII, protein C, protein S and antithrombin.

RESULTS

Of the entire study cohort, 40 patients (3.7%) had a prior myocardial infarction (MI), and 41 (3.8%) suffered a stroke. Other arterial thrombotic events were rare. Elevated factor VIII levels were more prevalent in MI patients than in controls (44.4 vs. 25.9%, p=0.044), but after adjusting for the traditional cardiovascular risk factors, this relationship was no longer significant. We observed a higher rate of lupus anticoagulant in MI patients with an adjusted odds ratio of 3.3 (95%CI 0.84-12.8, p=0.090). No difference in any other tested thrombophilia was observed in patients with MI or stroke relative to those without.

CONCLUSION

The cumulative incidence of arterial thrombotic events in VTE patients is low, and the inherited thrombophilias do not seem to substantially increase the risk of arterial thrombosis.

Authors+Show Affiliations

Division of Vascular Medicine, Department of Internal Medicine, Johann Wolfgang Goethe University Hospital, Theodor-Stern-Kai 7 D-60590 Frankfurt/Main, Germany. Birgit.Linnemann@kgu.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17804043

Citation

Linnemann, Birgit, et al. "Are Patients With Thrombophilia and Previous Venous Thromboembolism at Higher Risk to Arterial Thrombosis?" Thrombosis Research, vol. 121, no. 6, 2008, pp. 743-50.
Linnemann B, Schindewolf M, Zgouras D, et al. Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis? Thromb Res. 2008;121(6):743-50.
Linnemann, B., Schindewolf, M., Zgouras, D., Erbe, M., Jarosch-Preusche, M., & Lindhoff-Last, E. (2008). Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis? Thrombosis Research, 121(6), pp. 743-50.
Linnemann B, et al. Are Patients With Thrombophilia and Previous Venous Thromboembolism at Higher Risk to Arterial Thrombosis. Thromb Res. 2008;121(6):743-50. PubMed PMID: 17804043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis? AU - Linnemann,Birgit, AU - Schindewolf,Marc, AU - Zgouras,Dimitrios, AU - Erbe,Matthias, AU - Jarosch-Preusche,Marie, AU - Lindhoff-Last,Edelgard, Y1 - 2007/09/04/ PY - 2007/06/11/received PY - 2007/07/14/revised PY - 2007/07/18/accepted PY - 2007/9/7/pubmed PY - 2008/10/25/medline PY - 2007/9/7/entrez SP - 743 EP - 50 JF - Thrombosis research JO - Thromb. Res. VL - 121 IS - 6 N2 - INTRODUCTION: Whether thrombophilic disorders, which are established risk factors for venous thromboembolism (VTE), also increase the risk of arterial thrombosis is still unknown. MATERIALS AND METHODS: We analyzed data from 1081 consecutive patients (649 F/432 M, 16-93 years of age) with previous VTE registered in the MAISTHRO (MAin-ISar-THROmbosis) database with regard to arterial thrombotic events and contributing risk factors. Screening for thrombophilia included testing for factor V Leiden and prothrombin G20210A mutation, antiphospholipid antibodies and activities of factor VIII, protein C, protein S and antithrombin. RESULTS: Of the entire study cohort, 40 patients (3.7%) had a prior myocardial infarction (MI), and 41 (3.8%) suffered a stroke. Other arterial thrombotic events were rare. Elevated factor VIII levels were more prevalent in MI patients than in controls (44.4 vs. 25.9%, p=0.044), but after adjusting for the traditional cardiovascular risk factors, this relationship was no longer significant. We observed a higher rate of lupus anticoagulant in MI patients with an adjusted odds ratio of 3.3 (95%CI 0.84-12.8, p=0.090). No difference in any other tested thrombophilia was observed in patients with MI or stroke relative to those without. CONCLUSION: The cumulative incidence of arterial thrombotic events in VTE patients is low, and the inherited thrombophilias do not seem to substantially increase the risk of arterial thrombosis. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/17804043/Are_patients_with_thrombophilia_and_previous_venous_thromboembolism_at_higher_risk_to_arterial_thrombosis L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(07)00313-1 DB - PRIME DP - Unbound Medicine ER -