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Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes.
Diabetes Care. 2007 Dec; 30(12):2993-8.DC

Abstract

OBJECTIVE

The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study was to study the effect of fatty acids on postprandial insulin, glucose, and triglyceride responses.

RESEARCH DESIGN AND METHODS

Test meals rich in palmitic acid, linoleic acid, oleic acid, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and containing 1,000 kcal each were administered in a randomized crossover design to 11 type 2 diabetic subjects. Serum insulin, glucose, and triglyceride concentrations were measured for 360 min. All subjects received an isoenergetic diet of constant composition throughout the study.

RESULTS

According to repeated-measures ANOVA, the insulin (P = 0.0002) but not glucose (P = 0.10) response was significantly different between meals. The insulin response was lower to meals rich in oleic acid or EPA and DHA than to meals rich in palmitic acid or linoleic acid (P < 0.01). The triglyceride response did not reach statistical significance (P = 0.06) but tended to be lower with EPA and DHA than with the other fatty acids. Similar trends were seen for area under the curve (AUC) and incremental AUC for serum insulin and triglycerides, but the differences were not significant.

CONCLUSIONS

In comparison with palmitic acid and linoleic acid, oleic acid or EPA and DHA may modestly lower insulin response in patients with type 2 diabetes without deteriorating the glucose response. EPA and DHA may also reduce the triglyceride response.

Authors+Show Affiliations

Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17804680

Citation

Shah, Meena, et al. "Lipid, Glycemic, and Insulin Responses to Meals Rich in Saturated, Cis-monounsaturated, and Polyunsaturated (n-3 and N-6) Fatty Acids in Subjects With Type 2 Diabetes." Diabetes Care, vol. 30, no. 12, 2007, pp. 2993-8.
Shah M, Adams-Huet B, Brinkley L, et al. Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. Diabetes Care. 2007;30(12):2993-8.
Shah, M., Adams-Huet, B., Brinkley, L., Grundy, S. M., & Garg, A. (2007). Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. Diabetes Care, 30(12), 2993-8.
Shah M, et al. Lipid, Glycemic, and Insulin Responses to Meals Rich in Saturated, Cis-monounsaturated, and Polyunsaturated (n-3 and N-6) Fatty Acids in Subjects With Type 2 Diabetes. Diabetes Care. 2007;30(12):2993-8. PubMed PMID: 17804680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. AU - Shah,Meena, AU - Adams-Huet,Beverley, AU - Brinkley,Linda, AU - Grundy,Scott M, AU - Garg,Abhimanyu, Y1 - 2007/09/05/ PY - 2007/9/7/pubmed PY - 2008/2/9/medline PY - 2007/9/7/entrez SP - 2993 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 12 N2 - OBJECTIVE: The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study was to study the effect of fatty acids on postprandial insulin, glucose, and triglyceride responses. RESEARCH DESIGN AND METHODS: Test meals rich in palmitic acid, linoleic acid, oleic acid, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and containing 1,000 kcal each were administered in a randomized crossover design to 11 type 2 diabetic subjects. Serum insulin, glucose, and triglyceride concentrations were measured for 360 min. All subjects received an isoenergetic diet of constant composition throughout the study. RESULTS: According to repeated-measures ANOVA, the insulin (P = 0.0002) but not glucose (P = 0.10) response was significantly different between meals. The insulin response was lower to meals rich in oleic acid or EPA and DHA than to meals rich in palmitic acid or linoleic acid (P < 0.01). The triglyceride response did not reach statistical significance (P = 0.06) but tended to be lower with EPA and DHA than with the other fatty acids. Similar trends were seen for area under the curve (AUC) and incremental AUC for serum insulin and triglycerides, but the differences were not significant. CONCLUSIONS: In comparison with palmitic acid and linoleic acid, oleic acid or EPA and DHA may modestly lower insulin response in patients with type 2 diabetes without deteriorating the glucose response. EPA and DHA may also reduce the triglyceride response. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17804680/Lipid_glycemic_and_insulin_responses_to_meals_rich_in_saturated_cis_monounsaturated_and_polyunsaturated__n_3_and_n_6__fatty_acids_in_subjects_with_type_2_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17804680 DB - PRIME DP - Unbound Medicine ER -