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A comparison of propofol and thiopentone use in electroconvulsive therapy: cognitive and efficacy effects.
J ECT. 2007 Sep; 23(3):158-62.JE

Abstract

OBJECTIVE

The purpose of this study was to compare thiopentone and propofol administration for electroconvulsive therapy (ECT) in terms of associated efficacy and cognitive side effects in the immediate and medium term.

METHOD

Participants comprised 30 depressed patients who were administered either propofol or thiopentone as an anesthetic agent for ECT. Clinical rating scales and a battery of neuropsychological tests were administered at baseline, after 6 treatments, 1 to 3 days after treatment end point, and at 1-month follow-up.

RESULTS

Thiopentone administration was associated with advantages in efficacy and cognitive side effects compared with propofol administration.

CONCLUSIONS

This study reports some serendipitous findings regarding the comparative effects of the anesthetic agents, propofol and thiopentone. Although limited by small sample size, results suggest that thiopentone has advantages for use as an anesthetic agent with ECT compared with propofol. It also highlights the need for further investigation of the impact of anesthetic agents on the cognitive side effects and efficacy of ECT.

Authors+Show Affiliations

Department of Psychology, The University of Melbourne, Australia. Ingram@healthscope.com.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17804989

Citation

Ingram, Anna, et al. "A Comparison of Propofol and Thiopentone Use in Electroconvulsive Therapy: Cognitive and Efficacy Effects." The Journal of ECT, vol. 23, no. 3, 2007, pp. 158-62.
Ingram A, Schweitzer I, Ng CH, et al. A comparison of propofol and thiopentone use in electroconvulsive therapy: cognitive and efficacy effects. J ECT. 2007;23(3):158-62.
Ingram, A., Schweitzer, I., Ng, C. H., Saling, M. M., & Savage, G. (2007). A comparison of propofol and thiopentone use in electroconvulsive therapy: cognitive and efficacy effects. The Journal of ECT, 23(3), 158-62.
Ingram A, et al. A Comparison of Propofol and Thiopentone Use in Electroconvulsive Therapy: Cognitive and Efficacy Effects. J ECT. 2007;23(3):158-62. PubMed PMID: 17804989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of propofol and thiopentone use in electroconvulsive therapy: cognitive and efficacy effects. AU - Ingram,Anna, AU - Schweitzer,Isaac, AU - Ng,Chee H, AU - Saling,Michael M, AU - Savage,Greg, PY - 2007/9/7/pubmed PY - 2008/3/8/medline PY - 2007/9/7/entrez SP - 158 EP - 62 JF - The journal of ECT JO - J ECT VL - 23 IS - 3 N2 - OBJECTIVE: The purpose of this study was to compare thiopentone and propofol administration for electroconvulsive therapy (ECT) in terms of associated efficacy and cognitive side effects in the immediate and medium term. METHOD: Participants comprised 30 depressed patients who were administered either propofol or thiopentone as an anesthetic agent for ECT. Clinical rating scales and a battery of neuropsychological tests were administered at baseline, after 6 treatments, 1 to 3 days after treatment end point, and at 1-month follow-up. RESULTS: Thiopentone administration was associated with advantages in efficacy and cognitive side effects compared with propofol administration. CONCLUSIONS: This study reports some serendipitous findings regarding the comparative effects of the anesthetic agents, propofol and thiopentone. Although limited by small sample size, results suggest that thiopentone has advantages for use as an anesthetic agent with ECT compared with propofol. It also highlights the need for further investigation of the impact of anesthetic agents on the cognitive side effects and efficacy of ECT. SN - 1095-0680 UR - https://www.unboundmedicine.com/medline/citation/17804989/A_comparison_of_propofol_and_thiopentone_use_in_electroconvulsive_therapy:_cognitive_and_efficacy_effects_ L2 - https://doi.org/10.1097/yct.0b013e318070d1e9 DB - PRIME DP - Unbound Medicine ER -