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Low serum selenium is associated with anemia among older adults in the United States.
Eur J Clin Nutr. 2009 Jan; 63(1):93-9.EJ

Abstract

OBJECTIVE

We hypothesized that low serum selenium was associated with anemia in humans.

SUBJECTS

A total of 2092 adults aged 65 and older, in the third National Nutrition Examination Survey, Phase 2 (1991-1994) (NHANES III).

METHODS

Examination of the relationship between serum selenium and hematological indices in NHANES III.

RESULTS

Anemia, defined by World Health Organization criteria, was present in 12.9%. Mean serum selenium among non-anemic and anemic adults was 1.60 and 1.51 micromol l(-1) (P=0.0003). The prevalence of anemia among adults in the lowest to highest quartiles of serum selenium was 18.3, 9.5, 9.7 and 6.9%, respectively (P=0.0005). The proportion of adults in the lowest quartile of selenium among those who were non-anemic or who had anemia due to nutritional causes, chronic inflammation, renal disease or unexplained anemia was 9.9, 27.5, 17.5, 24.0 and 15.4%, respectively. An increase in log(e) selenium was associated with a reduced risk of anemia (odds ratio per one standard deviation increase 0.75, 95% confidence interval 0.58-0.97, P=0.03), adjusting for age, race, education, body mass index and chronic diseases.

CONCLUSION

Low serum selenium is independently associated with anemia among older men and women in the United States.

Authors+Show Affiliations

The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. rdsemba@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

17805227

Citation

Semba, R D., et al. "Low Serum Selenium Is Associated With Anemia Among Older Adults in the United States." European Journal of Clinical Nutrition, vol. 63, no. 1, 2009, pp. 93-9.
Semba RD, Ricks MO, Ferrucci L, et al. Low serum selenium is associated with anemia among older adults in the United States. Eur J Clin Nutr. 2009;63(1):93-9.
Semba, R. D., Ricks, M. O., Ferrucci, L., Xue, Q. L., Guralnik, J. M., & Fried, L. P. (2009). Low serum selenium is associated with anemia among older adults in the United States. European Journal of Clinical Nutrition, 63(1), 93-9.
Semba RD, et al. Low Serum Selenium Is Associated With Anemia Among Older Adults in the United States. Eur J Clin Nutr. 2009;63(1):93-9. PubMed PMID: 17805227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum selenium is associated with anemia among older adults in the United States. AU - Semba,R D, AU - Ricks,M O, AU - Ferrucci,L, AU - Xue,Q-L, AU - Guralnik,J M, AU - Fried,L P, Y1 - 2007/09/05/ PY - 2007/9/7/pubmed PY - 2009/2/20/medline PY - 2007/9/7/entrez SP - 93 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 1 N2 - OBJECTIVE: We hypothesized that low serum selenium was associated with anemia in humans. SUBJECTS: A total of 2092 adults aged 65 and older, in the third National Nutrition Examination Survey, Phase 2 (1991-1994) (NHANES III). METHODS: Examination of the relationship between serum selenium and hematological indices in NHANES III. RESULTS: Anemia, defined by World Health Organization criteria, was present in 12.9%. Mean serum selenium among non-anemic and anemic adults was 1.60 and 1.51 micromol l(-1) (P=0.0003). The prevalence of anemia among adults in the lowest to highest quartiles of serum selenium was 18.3, 9.5, 9.7 and 6.9%, respectively (P=0.0005). The proportion of adults in the lowest quartile of selenium among those who were non-anemic or who had anemia due to nutritional causes, chronic inflammation, renal disease or unexplained anemia was 9.9, 27.5, 17.5, 24.0 and 15.4%, respectively. An increase in log(e) selenium was associated with a reduced risk of anemia (odds ratio per one standard deviation increase 0.75, 95% confidence interval 0.58-0.97, P=0.03), adjusting for age, race, education, body mass index and chronic diseases. CONCLUSION: Low serum selenium is independently associated with anemia among older men and women in the United States. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/17805227/Low_serum_selenium_is_associated_with_anemia_among_older_adults_in_the_United_States_ L2 - https://doi.org/10.1038/sj.ejcn.1602889 DB - PRIME DP - Unbound Medicine ER -