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The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis.
Clin Infect Dis 2007; 45(7):866-71CI

Abstract

BACKGROUND

There are few studies on coinfection with genital mycoplasmas and ureaplasmas in men with gonococcal urethritis (GU). The role of these species in postgonococcal urethritis (PGU) is poorly understood. Thus, we conducted a study to determine the prevalence of coinfection with genital mycoplasmas and ureaplasmas among men with GU and to assess the role of these pathogens in PGU.

METHODS

Three hundred ninety men infected with culture-confirmed Neisseria gonorrhoeae participated in the study. Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum biovar 1, and Ureaplasma urealyticum biovar 2 in first-voided urine samples were detected by polymerase chain reaction-based assay at the patients' initial visits. PGU was judged to be present if the urethral smear was positive for polymorphonuclear leucocytes 7-14 days after treatment for gonorrhea. The association between each microorganism and PGU, measured by the odds ratio, was estimated by multivariate logistic regression analysis.

RESULTS

C. trachomatis, M. genitalium, M. hominis, U. parvum biovar 1, and U. urealyticum biovar 2 were detected in 85 (21.8%), 16 (4.1%), 8 (2.1%), and 33 men (8.5%), respectively. In patients with chlamydia-negative GU, coinfection with M. genitalium was associated with a 14.54-fold greater risk of PGU (95% confidence interval, 2.91-72.74), and coinfection with U. urealyticum biovar 2 was associated with a 3.64-fold greater risk of PGU (95% confidence interval, 1.24-10.63).

CONCLUSIONS

Coinfection with M. genitalium or U. ureaplasma biovar 2 in men with GU was significantly associated with PGU, independent of C. trachomatis. Men with GU should be treated presumptively with antibiotics that are active against C. trachomatis, M. genitalium, and U. urealyticum biovar 2.

Authors+Show Affiliations

Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17806051

Citation

Yokoi, Shigeaki, et al. "The Role of Mycoplasma Genitalium and Ureaplasma Urealyticum Biovar 2 in Postgonococcal Urethritis." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 45, no. 7, 2007, pp. 866-71.
Yokoi S, Maeda S, Kubota Y, et al. The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis. Clin Infect Dis. 2007;45(7):866-71.
Yokoi, S., Maeda, S., Kubota, Y., Tamaki, M., Mizutani, K., Yasuda, M., ... Deguchi, T. (2007). The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 45(7), pp. 866-71.
Yokoi S, et al. The Role of Mycoplasma Genitalium and Ureaplasma Urealyticum Biovar 2 in Postgonococcal Urethritis. Clin Infect Dis. 2007 Oct 1;45(7):866-71. PubMed PMID: 17806051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis. AU - Yokoi,Shigeaki, AU - Maeda,Shin-ichi, AU - Kubota,Yasuaki, AU - Tamaki,Masayoshi, AU - Mizutani,Kohsuke, AU - Yasuda,Mitsuru, AU - Ito,Shin-ichi, AU - Nakano,Masahiro, AU - Ehara,Hidetoshi, AU - Deguchi,Takashi, Y1 - 2007/08/20/ PY - 2007/01/22/received PY - 2007/05/10/accepted PY - 2007/9/7/pubmed PY - 2007/10/3/medline PY - 2007/9/7/entrez SP - 866 EP - 71 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 45 IS - 7 N2 - BACKGROUND: There are few studies on coinfection with genital mycoplasmas and ureaplasmas in men with gonococcal urethritis (GU). The role of these species in postgonococcal urethritis (PGU) is poorly understood. Thus, we conducted a study to determine the prevalence of coinfection with genital mycoplasmas and ureaplasmas among men with GU and to assess the role of these pathogens in PGU. METHODS: Three hundred ninety men infected with culture-confirmed Neisseria gonorrhoeae participated in the study. Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum biovar 1, and Ureaplasma urealyticum biovar 2 in first-voided urine samples were detected by polymerase chain reaction-based assay at the patients' initial visits. PGU was judged to be present if the urethral smear was positive for polymorphonuclear leucocytes 7-14 days after treatment for gonorrhea. The association between each microorganism and PGU, measured by the odds ratio, was estimated by multivariate logistic regression analysis. RESULTS: C. trachomatis, M. genitalium, M. hominis, U. parvum biovar 1, and U. urealyticum biovar 2 were detected in 85 (21.8%), 16 (4.1%), 8 (2.1%), and 33 men (8.5%), respectively. In patients with chlamydia-negative GU, coinfection with M. genitalium was associated with a 14.54-fold greater risk of PGU (95% confidence interval, 2.91-72.74), and coinfection with U. urealyticum biovar 2 was associated with a 3.64-fold greater risk of PGU (95% confidence interval, 1.24-10.63). CONCLUSIONS: Coinfection with M. genitalium or U. ureaplasma biovar 2 in men with GU was significantly associated with PGU, independent of C. trachomatis. Men with GU should be treated presumptively with antibiotics that are active against C. trachomatis, M. genitalium, and U. urealyticum biovar 2. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/17806051/The_role_of_Mycoplasma_genitalium_and_Ureaplasma_urealyticum_biovar_2_in_postgonococcal_urethritis_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/521266 DB - PRIME DP - Unbound Medicine ER -