Tags

Type your tag names separated by a space and hit enter

[Microangiopathies in chronic venous insufficiency (CVI)].
Ther Umsch. 1991 Oct; 48(10):715-21.TU

Abstract

The degree of cutaneous microangiopathy at the medial ankle correlates with the severity of chronic venous insufficiency, most probably it is the trigger factor for development of trophic skin lesions. Using intravital fluorescence videomicroscopy, microlymphography, transcutaneous oxygen tension measurement and laser Doppler flowmetry, the microangiopathy is characterized by morphological alterations of blood and lymph capillaries and by dynamic changes (decreased transcutaneous oxygen tension reflecting microvascular ischemia, increased skin perfusion). Microangiopathy in patients with chronic venous insufficiency is recognized by the presence of dilated, elongated and tortuous (glomerulus-like) capillaries and by an increase in diameter of the pericapillary space (halo) filled by Na-fluorescein. In severe CVI a reduction of the capillary number can be observed, probably as a result of previous capillary thrombosis. Lymphatic drainage is disturbed and lymph capillaries are obliterated in part. Laser Doppler flowmetry, which detects flux in deeper, non-nutrient skin vessels, shows increased blood flow. However, the postural vasoconstrictive response remains intact and there is little alteration in the spontaneous rhythmic flux waves. In contrast to deeper skin flux transcutaneous oxygen tension is reduced, in keeping with the microangiopathy observed in the superficial nutrient capillaries. These pronounced morphological and dynamic changes explain the development of trophic skin lesions.

Authors+Show Affiliations

Leu AJ
Department für Innere Medizin, Universitätsspital, Zürich.
Franzeck UK
No affiliation info available
Bollinger A
No affiliation info available

MeSH

Blood Gas Monitoring, TranscutaneousHumansLymphographyMicrocirculationMicroscopy, FluorescenceSkinUltrasonographyVascular DiseasesVenous Insufficiency

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

1780801

Citation

Leu, A J., et al. "[Microangiopathies in Chronic Venous Insufficiency (CVI)]." Therapeutische Umschau. Revue Therapeutique, vol. 48, no. 10, 1991, pp. 715-21.
Leu AJ, Franzeck UK, Bollinger A. [Microangiopathies in chronic venous insufficiency (CVI)]. Ther Umsch. 1991;48(10):715-21.
Leu, A. J., Franzeck, U. K., & Bollinger, A. (1991). [Microangiopathies in chronic venous insufficiency (CVI)]. Therapeutische Umschau. Revue Therapeutique, 48(10), 715-21.
Leu AJ, Franzeck UK, Bollinger A. [Microangiopathies in Chronic Venous Insufficiency (CVI)]. Ther Umsch. 1991;48(10):715-21. PubMed PMID: 1780801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Microangiopathies in chronic venous insufficiency (CVI)]. AU - Leu,A J, AU - Franzeck,U K, AU - Bollinger,A, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 715 EP - 21 JF - Therapeutische Umschau. Revue therapeutique JO - Ther Umsch VL - 48 IS - 10 N2 - The degree of cutaneous microangiopathy at the medial ankle correlates with the severity of chronic venous insufficiency, most probably it is the trigger factor for development of trophic skin lesions. Using intravital fluorescence videomicroscopy, microlymphography, transcutaneous oxygen tension measurement and laser Doppler flowmetry, the microangiopathy is characterized by morphological alterations of blood and lymph capillaries and by dynamic changes (decreased transcutaneous oxygen tension reflecting microvascular ischemia, increased skin perfusion). Microangiopathy in patients with chronic venous insufficiency is recognized by the presence of dilated, elongated and tortuous (glomerulus-like) capillaries and by an increase in diameter of the pericapillary space (halo) filled by Na-fluorescein. In severe CVI a reduction of the capillary number can be observed, probably as a result of previous capillary thrombosis. Lymphatic drainage is disturbed and lymph capillaries are obliterated in part. Laser Doppler flowmetry, which detects flux in deeper, non-nutrient skin vessels, shows increased blood flow. However, the postural vasoconstrictive response remains intact and there is little alteration in the spontaneous rhythmic flux waves. In contrast to deeper skin flux transcutaneous oxygen tension is reduced, in keeping with the microangiopathy observed in the superficial nutrient capillaries. These pronounced morphological and dynamic changes explain the development of trophic skin lesions. SN - 0040-5930 UR - https://www.unboundmedicine.com/medline/citation/1780801/[Microangiopathies_in_chronic_venous_insufficiency__CVI_]_ L2 - https://medlineplus.gov/vasculardiseases.html DB - PRIME DP - Unbound Medicine ER -