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Postprandial plasma triglyceride and cholesterol responses to a low-fat meal.
Am J Clin Nutr 1976; 29(5):535-9AJ

Abstract

Postprandial plasma cholesterol and triglyceride (TG) levels were measured after the consumption of a relatively low-fat (35% of calories) diet in 41 subjects. Plasma cholesterol levels did not change appreciably during the postprandial state. In 34 subjects a biphasic plasma TG response curve was noted, with an initial peak occurring 1 to 3 hr after feeding and a secondary TG peak 4 to 7 hr after the meal. The primary peak was greater than 90%, accounted for by chylomicrons, whereas the secondary peak represented very low-density lipoproteins (greater than 82%). Furthermore, the heights of the primary and secondary peaks were closely correlated to the fasting TG level (r = 0.61 and 0.72, respectively) indicating that the fasting TG concentration is an important determinant of the postprandial TG response. Because low-fat (high-carbohydrate) diets are known to raise fasting TG levels in patients who do not have fasting hyperchylomicronemia, and because relatively few patients have chylomicrons in the fasting state, these data suggest that such diets may lead to day long increases in plasma TG levels in the majority of subjects.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

178167

Citation

Olefsky, J M., et al. "Postprandial Plasma Triglyceride and Cholesterol Responses to a Low-fat Meal." The American Journal of Clinical Nutrition, vol. 29, no. 5, 1976, pp. 535-9.
Olefsky JM, Crapo P, Reaven GM. Postprandial plasma triglyceride and cholesterol responses to a low-fat meal. Am J Clin Nutr. 1976;29(5):535-9.
Olefsky, J. M., Crapo, P., & Reaven, G. M. (1976). Postprandial plasma triglyceride and cholesterol responses to a low-fat meal. The American Journal of Clinical Nutrition, 29(5), pp. 535-9.
Olefsky JM, Crapo P, Reaven GM. Postprandial Plasma Triglyceride and Cholesterol Responses to a Low-fat Meal. Am J Clin Nutr. 1976;29(5):535-9. PubMed PMID: 178167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial plasma triglyceride and cholesterol responses to a low-fat meal. AU - Olefsky,J M, AU - Crapo,P, AU - Reaven,G M, PY - 1976/5/1/pubmed PY - 1976/5/1/medline PY - 1976/5/1/entrez SP - 535 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 29 IS - 5 N2 - Postprandial plasma cholesterol and triglyceride (TG) levels were measured after the consumption of a relatively low-fat (35% of calories) diet in 41 subjects. Plasma cholesterol levels did not change appreciably during the postprandial state. In 34 subjects a biphasic plasma TG response curve was noted, with an initial peak occurring 1 to 3 hr after feeding and a secondary TG peak 4 to 7 hr after the meal. The primary peak was greater than 90%, accounted for by chylomicrons, whereas the secondary peak represented very low-density lipoproteins (greater than 82%). Furthermore, the heights of the primary and secondary peaks were closely correlated to the fasting TG level (r = 0.61 and 0.72, respectively) indicating that the fasting TG concentration is an important determinant of the postprandial TG response. Because low-fat (high-carbohydrate) diets are known to raise fasting TG levels in patients who do not have fasting hyperchylomicronemia, and because relatively few patients have chylomicrons in the fasting state, these data suggest that such diets may lead to day long increases in plasma TG levels in the majority of subjects. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/178167/Postprandial_plasma_triglyceride_and_cholesterol_responses_to_a_low_fat_meal_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/29.5.535 DB - PRIME DP - Unbound Medicine ER -