Tags

Type your tag names separated by a space and hit enter

Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study.
Allergy. 2007 Dec; 62(12):1379-86.A

Abstract

BACKGROUND

Atopy quantification using IgE levels/skin test diameter (SPT-MWD) may better predict the expression of rhinitis than using atopy as a dichotomous variable.

OBJECTIVE

To investigate the association between the presence, temporal pattern and severity of rhinitis in preschool children and specific IgE levels/SPT-MWDs.

METHODS

Children were followed prospectively to age 5 years in a whole-population birth cohort study. We administered questionnaires (n = 815), skin prick tested children (n = 717) and measured specific serum IgE (n = 478) to inhalant and food allergens. Main outcomes were current rhinitis (CR) and current rhinoconjunctivitis (CRC).

RESULTS

The prevalence of CR and CRC was 26.1% and 12.1%, respectively. The risk of CR and CRC increased significantly with increasing IgE to grass, mite and cat; CRC was also associated with increasing IgE to dog and peanut. Similarly, increasing SPT-MWDs to inhalant allergens were significantly associated with CR and CRC. This association was also shown for grass within the group of atopic children. Perennial and seasonal rhinitis were associated with increasing IgE/SPT-MWD to mite and grass, respectively. Moderate/severe rhinitis was associated with increasing IgE/SPT-MWD to grass. In a multivariate analysis, increasing levels of IgE/SPT-MWD to grass were the strongest independent predictors of both CR (for IgE: OR 1.42, 95% CI 1.23-1.64, P < 0.001) and CRC (for IgE: 1.51, 1.30-1.76, P < 0.001).

CONCLUSION

The probability of CR/CRC increases with increasing specific IgE levels or SPT-MWD. With respect to allergic rhinitis, the absolute levels of specific IgE antibody or the size of SPT wheal offer more information than just the presence/absence of sensitization.

Authors+Show Affiliations

Academic Division of Medicine and Surgery, University of Manchester, Manchester, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17822449

Citation

Marinho, S, et al. "Quantification of Atopy and the Probability of Rhinitis in Preschool Children: a Population-based Birth Cohort Study." Allergy, vol. 62, no. 12, 2007, pp. 1379-86.
Marinho S, Simpson A, Söderström L, et al. Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. Allergy. 2007;62(12):1379-86.
Marinho, S., Simpson, A., Söderström, L., Woodcock, A., Ahlstedt, S., & Custovic, A. (2007). Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. Allergy, 62(12), 1379-86.
Marinho S, et al. Quantification of Atopy and the Probability of Rhinitis in Preschool Children: a Population-based Birth Cohort Study. Allergy. 2007;62(12):1379-86. PubMed PMID: 17822449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. AU - Marinho,S, AU - Simpson,A, AU - Söderström,L, AU - Woodcock,A, AU - Ahlstedt,S, AU - Custovic,A, Y1 - 2007/09/05/ PY - 2007/9/8/pubmed PY - 2008/1/23/medline PY - 2007/9/8/entrez SP - 1379 EP - 86 JF - Allergy JO - Allergy VL - 62 IS - 12 N2 - BACKGROUND: Atopy quantification using IgE levels/skin test diameter (SPT-MWD) may better predict the expression of rhinitis than using atopy as a dichotomous variable. OBJECTIVE: To investigate the association between the presence, temporal pattern and severity of rhinitis in preschool children and specific IgE levels/SPT-MWDs. METHODS: Children were followed prospectively to age 5 years in a whole-population birth cohort study. We administered questionnaires (n = 815), skin prick tested children (n = 717) and measured specific serum IgE (n = 478) to inhalant and food allergens. Main outcomes were current rhinitis (CR) and current rhinoconjunctivitis (CRC). RESULTS: The prevalence of CR and CRC was 26.1% and 12.1%, respectively. The risk of CR and CRC increased significantly with increasing IgE to grass, mite and cat; CRC was also associated with increasing IgE to dog and peanut. Similarly, increasing SPT-MWDs to inhalant allergens were significantly associated with CR and CRC. This association was also shown for grass within the group of atopic children. Perennial and seasonal rhinitis were associated with increasing IgE/SPT-MWD to mite and grass, respectively. Moderate/severe rhinitis was associated with increasing IgE/SPT-MWD to grass. In a multivariate analysis, increasing levels of IgE/SPT-MWD to grass were the strongest independent predictors of both CR (for IgE: OR 1.42, 95% CI 1.23-1.64, P < 0.001) and CRC (for IgE: 1.51, 1.30-1.76, P < 0.001). CONCLUSION: The probability of CR/CRC increases with increasing specific IgE levels or SPT-MWD. With respect to allergic rhinitis, the absolute levels of specific IgE antibody or the size of SPT wheal offer more information than just the presence/absence of sensitization. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/17822449/Quantification_of_atopy_and_the_probability_of_rhinitis_in_preschool_children:_a_population_based_birth_cohort_study_ L2 - https://doi.org/10.1111/j.1398-9995.2007.01502.x DB - PRIME DP - Unbound Medicine ER -