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Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.
Food Chem Toxicol. 2008 Jan; 46(1):168-74.FC

Abstract

Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both D-kawain and DL-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation.

Authors+Show Affiliations

Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA. paul.whittaker@fda.hhs.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17822821

Citation

Whittaker, Paul, et al. "Evaluation of Commercial Kava Extracts and Kavalactone Standards for Mutagenicity and Toxicity Using the Mammalian Cell Gene Mutation Assay in L5178Y Mouse Lymphoma Cells." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 1, 2008, pp. 168-74.
Whittaker P, Clarke JJ, San RH, et al. Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Food Chem Toxicol. 2008;46(1):168-74.
Whittaker, P., Clarke, J. J., San, R. H., Betz, J. M., Seifried, H. E., de Jager, L. S., & Dunkel, V. C. (2008). Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(1), 168-74.
Whittaker P, et al. Evaluation of Commercial Kava Extracts and Kavalactone Standards for Mutagenicity and Toxicity Using the Mammalian Cell Gene Mutation Assay in L5178Y Mouse Lymphoma Cells. Food Chem Toxicol. 2008;46(1):168-74. PubMed PMID: 17822821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. AU - Whittaker,Paul, AU - Clarke,Jane J, AU - San,Richard H C, AU - Betz,Joseph M, AU - Seifried,Harold E, AU - de Jager,Lowri S, AU - Dunkel,Virginia C, Y1 - 2007/07/31/ PY - 2007/05/11/received PY - 2007/07/03/revised PY - 2007/07/17/accepted PY - 2007/9/8/pubmed PY - 2008/3/12/medline PY - 2007/9/8/entrez SP - 168 EP - 74 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 1 N2 - Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both D-kawain and DL-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/17822821/Evaluation_of_commercial_kava_extracts_and_kavalactone_standards_for_mutagenicity_and_toxicity_using_the_mammalian_cell_gene_mutation_assay_in_L5178Y_mouse_lymphoma_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(07)00260-8 DB - PRIME DP - Unbound Medicine ER -