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Multifocal blue-on-yellow visual evoked potentials in early glaucoma.
Ophthalmology. 2007 Sep; 114(9):1613-21.O

Abstract

OBJECTIVE

To determine the sensitivity and specificity of blue-on-yellow multifocal visual evoked potentials (mfVEPs) in early glaucoma.

DESIGN

Cross-sectional study.

PARTICIPANTS

Fifty patients with a confirmed diagnosis of early glaucoma and 60 normal participants.

METHODS

Black-and-white mfVEPs and blue-on-yellow mfVEPs were recorded using the Accumap version 2.0 (ObjectiVision Pty. Ltd., Sydney, Australia). All patients also underwent achromatic standard automated perimetry (SAP).

MAIN OUTCOME MEASURES

Multifocal VEP amplitude and latency values in glaucoma patients were analyzed and compared with those of the normal controls.

RESULTS

Based on the definition of visual field defect, in the group of glaucomatous eyes with SAP defects, amplitude of blue-on-yellow mfVEP was abnormal in all 64 cases (100% sensitivity), whereas black-and-white mfVEP missed 5 cases (92.2% sensitivity). Generally, larger scotomata were noted on blue-on-yellow mfVEP compared with black-and-white mfVEP for the same eyes. There was high topographic correspondence between SAP and amplitude of blue-on-yellow mfVEP and significant (P<0.0001) correlation between them (correlation coefficient, 0.73). Abnormal amplitude was detected in 3 of 60 eyes of control subjects (95% specificity). There was, however, no correlation between visual field defect and latency delay in glaucoma patients. Although there was a significant difference between averaged latency of control and glaucoma eyes, values considerably overlapped.

CONCLUSIONS

The blue-on-yellow mfVEP is a sensitive and specific tool for detecting early glaucoma based on amplitude analysis.

Authors+Show Affiliations

Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17822971

Citation

Klistorner, Alexander, et al. "Multifocal Blue-on-yellow Visual Evoked Potentials in Early Glaucoma." Ophthalmology, vol. 114, no. 9, 2007, pp. 1613-21.
Klistorner A, Graham SL, Martins A, et al. Multifocal blue-on-yellow visual evoked potentials in early glaucoma. Ophthalmology. 2007;114(9):1613-21.
Klistorner, A., Graham, S. L., Martins, A., Grigg, J. R., Arvind, H., Kumar, R. S., James, A. C., & Billson, F. A. (2007). Multifocal blue-on-yellow visual evoked potentials in early glaucoma. Ophthalmology, 114(9), 1613-21.
Klistorner A, et al. Multifocal Blue-on-yellow Visual Evoked Potentials in Early Glaucoma. Ophthalmology. 2007;114(9):1613-21. PubMed PMID: 17822971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifocal blue-on-yellow visual evoked potentials in early glaucoma. AU - Klistorner,Alexander, AU - Graham,Stuart L, AU - Martins,Alessandra, AU - Grigg,John R, AU - Arvind,Hemamalini, AU - Kumar,Rajesh S, AU - James,Andrew C, AU - Billson,Francis A, PY - 2006/06/27/received PY - 2006/11/23/revised PY - 2006/11/28/accepted PY - 2007/9/8/pubmed PY - 2007/9/19/medline PY - 2007/9/8/entrez SP - 1613 EP - 21 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 9 N2 - OBJECTIVE: To determine the sensitivity and specificity of blue-on-yellow multifocal visual evoked potentials (mfVEPs) in early glaucoma. DESIGN: Cross-sectional study. PARTICIPANTS: Fifty patients with a confirmed diagnosis of early glaucoma and 60 normal participants. METHODS: Black-and-white mfVEPs and blue-on-yellow mfVEPs were recorded using the Accumap version 2.0 (ObjectiVision Pty. Ltd., Sydney, Australia). All patients also underwent achromatic standard automated perimetry (SAP). MAIN OUTCOME MEASURES: Multifocal VEP amplitude and latency values in glaucoma patients were analyzed and compared with those of the normal controls. RESULTS: Based on the definition of visual field defect, in the group of glaucomatous eyes with SAP defects, amplitude of blue-on-yellow mfVEP was abnormal in all 64 cases (100% sensitivity), whereas black-and-white mfVEP missed 5 cases (92.2% sensitivity). Generally, larger scotomata were noted on blue-on-yellow mfVEP compared with black-and-white mfVEP for the same eyes. There was high topographic correspondence between SAP and amplitude of blue-on-yellow mfVEP and significant (P<0.0001) correlation between them (correlation coefficient, 0.73). Abnormal amplitude was detected in 3 of 60 eyes of control subjects (95% specificity). There was, however, no correlation between visual field defect and latency delay in glaucoma patients. Although there was a significant difference between averaged latency of control and glaucoma eyes, values considerably overlapped. CONCLUSIONS: The blue-on-yellow mfVEP is a sensitive and specific tool for detecting early glaucoma based on amplitude analysis. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17822971/Multifocal_blue_on_yellow_visual_evoked_potentials_in_early_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)01669-1 DB - PRIME DP - Unbound Medicine ER -