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Long-term effect of 1-piece and 3-piece hydrophobic acrylic intraocular lens on posterior capsule opacification: a randomized trial.
Ophthalmology. 2007 Sep; 114(9):1663-9.O

Abstract

PURPOSE

To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of the foldable hydrophobic acrylic AcrySof intraocular lens (IOL) over a 5-year period.

DESIGN

Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison.

PARTICIPANTS

Fifty-two patients with bilateral age-related cataract (104 eyes).

METHODS

Each study patient had cataract surgery in both eyes and received a 1-piece AcrySof IOL in 1 eye and a 3-piece AcrySof IOL in the other eye. Follow-up examinations were performed at 1 week, 1 month, 6 months, and 1, 2, and 5 years. Digital retroillumination images were obtained of each eye. The amount of posterior capsule opacification (score range, 0-10) was assessed subjectively at the slit lamp and objectively using automated image analysis software 1, 2, and 5 years after surgery.

MAIN OUTCOME MEASURE

Posterior capsule opacification score (scale, 0-10).

RESULTS

There was no significant difference between the 1-piece and 3-piece AcrySof IOL in best-corrected visual acuity, overlap of rhexis and IOL, capsular folds, anterior capsule opacification, and posterior capsule opacification (1-piece AcrySof PCO score, 1.7+/-1.7; 3-piece AcrySof PCO score, 1.3+/-1.4; P = 0.30).

CONCLUSIONS

Modification of the IOL haptic design of the sharp optic edged AcrySof IOL from a 3-piece to a 1-piece haptic design caused no significant change in PCO intensity and neodymium:yttrium-aluminium-garnet laser treatment rate 5 years after surgery.

Authors+Show Affiliations

Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. christina.leydolt@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17822973

Citation

Leydolt, Christina, et al. "Long-term Effect of 1-piece and 3-piece Hydrophobic Acrylic Intraocular Lens On Posterior Capsule Opacification: a Randomized Trial." Ophthalmology, vol. 114, no. 9, 2007, pp. 1663-9.
Leydolt C, Davidovic S, Sacu S, et al. Long-term effect of 1-piece and 3-piece hydrophobic acrylic intraocular lens on posterior capsule opacification: a randomized trial. Ophthalmology. 2007;114(9):1663-9.
Leydolt, C., Davidovic, S., Sacu, S., Menapace, R., Neumayer, T., Prinz, A., Buehl, W., & Findl, O. (2007). Long-term effect of 1-piece and 3-piece hydrophobic acrylic intraocular lens on posterior capsule opacification: a randomized trial. Ophthalmology, 114(9), 1663-9.
Leydolt C, et al. Long-term Effect of 1-piece and 3-piece Hydrophobic Acrylic Intraocular Lens On Posterior Capsule Opacification: a Randomized Trial. Ophthalmology. 2007;114(9):1663-9. PubMed PMID: 17822973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effect of 1-piece and 3-piece hydrophobic acrylic intraocular lens on posterior capsule opacification: a randomized trial. AU - Leydolt,Christina, AU - Davidovic,Sofija, AU - Sacu,Stefan, AU - Menapace,Rupert, AU - Neumayer,Thomas, AU - Prinz,Ana, AU - Buehl,Wolf, AU - Findl,Oliver, PY - 2006/06/23/received PY - 2006/12/11/revised PY - 2006/12/11/accepted PY - 2007/9/8/pubmed PY - 2007/9/19/medline PY - 2007/9/8/entrez SP - 1663 EP - 9 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 9 N2 - PURPOSE: To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of the foldable hydrophobic acrylic AcrySof intraocular lens (IOL) over a 5-year period. DESIGN: Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison. PARTICIPANTS: Fifty-two patients with bilateral age-related cataract (104 eyes). METHODS: Each study patient had cataract surgery in both eyes and received a 1-piece AcrySof IOL in 1 eye and a 3-piece AcrySof IOL in the other eye. Follow-up examinations were performed at 1 week, 1 month, 6 months, and 1, 2, and 5 years. Digital retroillumination images were obtained of each eye. The amount of posterior capsule opacification (score range, 0-10) was assessed subjectively at the slit lamp and objectively using automated image analysis software 1, 2, and 5 years after surgery. MAIN OUTCOME MEASURE: Posterior capsule opacification score (scale, 0-10). RESULTS: There was no significant difference between the 1-piece and 3-piece AcrySof IOL in best-corrected visual acuity, overlap of rhexis and IOL, capsular folds, anterior capsule opacification, and posterior capsule opacification (1-piece AcrySof PCO score, 1.7+/-1.7; 3-piece AcrySof PCO score, 1.3+/-1.4; P = 0.30). CONCLUSIONS: Modification of the IOL haptic design of the sharp optic edged AcrySof IOL from a 3-piece to a 1-piece haptic design caused no significant change in PCO intensity and neodymium:yttrium-aluminium-garnet laser treatment rate 5 years after surgery. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17822973/Long_term_effect_of_1_piece_and_3_piece_hydrophobic_acrylic_intraocular_lens_on_posterior_capsule_opacification:_a_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)01664-2 DB - PRIME DP - Unbound Medicine ER -