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Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies.
Am J Epidemiol. 2007 Nov 15; 166(10):1116-25.AJ

Abstract

Animal studies show favorable effects of n-3 fatty acids on inflammation and cancer, but results from epidemiologic studies appear to be inconsistent. The authors conducted meta-analyses of prospective cohort studies that evaluated the association between fish consumption or n-3 fatty acids and colorectal cancer incidence or mortality. Random-effects models were used, and heterogeneity between study results was explored through stratified analyses. The pooled relative risks for the highest compared with the lowest fish consumption category were 0.88 (95% confidence interval: 0.78, 1.00) for colorectal cancer incidence (14 studies) and 1.02 (95% confidence interval: 0.90, 1.16) for colorectal cancer mortality (four studies). The pooled relative risks for colorectal cancer incidence were 0.96 (95% confidence interval: 0.92, 1.00) for each extra occurrence of fish consumption per week (seven studies) and 0.97 (95% confidence interval: 0.92, 1.03) for each extra 100 g of fish consumed per week (four studies). Stratified analysis showed that the pooled relative risk for colorectal cancer incidence was more pronounced for women and in studies with a large exposure contrast. In cohort studies, fish consumption was shown to slightly reduce colorectal cancer risk. Existing evidence that n-3 fatty acids inhibit colorectal carcinogenesis is in line with these results, but few data are available addressing this association.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. anouk.geelen@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17823383

Citation

Geelen, Anouk, et al. "Fish Consumption, N-3 Fatty Acids, and Colorectal Cancer: a Meta-analysis of Prospective Cohort Studies." American Journal of Epidemiology, vol. 166, no. 10, 2007, pp. 1116-25.
Geelen A, Schouten JM, Kamphuis C, et al. Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies. Am J Epidemiol. 2007;166(10):1116-25.
Geelen, A., Schouten, J. M., Kamphuis, C., Stam, B. E., Burema, J., Renkema, J. M., Bakker, E. J., van't Veer, P., & Kampman, E. (2007). Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies. American Journal of Epidemiology, 166(10), 1116-25.
Geelen A, et al. Fish Consumption, N-3 Fatty Acids, and Colorectal Cancer: a Meta-analysis of Prospective Cohort Studies. Am J Epidemiol. 2007 Nov 15;166(10):1116-25. PubMed PMID: 17823383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies. AU - Geelen,Anouk, AU - Schouten,Jannigje M, AU - Kamphuis,Claudia, AU - Stam,Bianca E, AU - Burema,Jan, AU - Renkema,Jacoba M S, AU - Bakker,Evert-Jan, AU - van't Veer,Pieter, AU - Kampman,Ellen, Y1 - 2007/09/06/ PY - 2007/9/8/pubmed PY - 2007/12/6/medline PY - 2007/9/8/entrez SP - 1116 EP - 25 JF - American journal of epidemiology JO - Am J Epidemiol VL - 166 IS - 10 N2 - Animal studies show favorable effects of n-3 fatty acids on inflammation and cancer, but results from epidemiologic studies appear to be inconsistent. The authors conducted meta-analyses of prospective cohort studies that evaluated the association between fish consumption or n-3 fatty acids and colorectal cancer incidence or mortality. Random-effects models were used, and heterogeneity between study results was explored through stratified analyses. The pooled relative risks for the highest compared with the lowest fish consumption category were 0.88 (95% confidence interval: 0.78, 1.00) for colorectal cancer incidence (14 studies) and 1.02 (95% confidence interval: 0.90, 1.16) for colorectal cancer mortality (four studies). The pooled relative risks for colorectal cancer incidence were 0.96 (95% confidence interval: 0.92, 1.00) for each extra occurrence of fish consumption per week (seven studies) and 0.97 (95% confidence interval: 0.92, 1.03) for each extra 100 g of fish consumed per week (four studies). Stratified analysis showed that the pooled relative risk for colorectal cancer incidence was more pronounced for women and in studies with a large exposure contrast. In cohort studies, fish consumption was shown to slightly reduce colorectal cancer risk. Existing evidence that n-3 fatty acids inhibit colorectal carcinogenesis is in line with these results, but few data are available addressing this association. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/17823383/Fish_consumption_n_3_fatty_acids_and_colorectal_cancer:_a_meta_analysis_of_prospective_cohort_studies_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm197 DB - PRIME DP - Unbound Medicine ER -