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The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients.
Blood Coagul Fibrinolysis. 1991 Oct; 2(5):673-8.BC

Abstract

It is well established that pregnancy and puerperium, surgery and trauma may often trigger thrombotic events even in the normal population. On the other hand, patients with congenital deficiency of clotting inhibitors may develop spontaneous thrombotic episodes, although they become often symptomatic when one of the above-mentioned triggering factors is present. We found this to be true in 40 out of 81 symptomatic patients with congenital defects of coagulation inhibitors. In six (15%) of these cases medications (mainly oral contraceptives) triggered the thrombotic event. The incidence of pharmacological factors as a cause of thrombosis is commonly maintained to be low. This study indicates that this is not so and underlines the potential importance of drugs, particularly oral contraceptives, in the pathogenesis of thrombotic events in patients with congenital defects of clotting inhibitors.

Authors+Show Affiliations

Institute of Medical Semeiotics, Fourth Chair of Internal Medicine, Padua, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1782339

Citation

Girolami, A, et al. "The Role of Drugs, Particularly Oral Contraceptives, in Triggering Thrombosis in Congenital Defects of Coagulation Inhibitors: a Study of Six Patients." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 2, no. 5, 1991, pp. 673-8.
Girolami A, Simioni P, Girolami B, et al. The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients. Blood Coagul Fibrinolysis. 1991;2(5):673-8.
Girolami, A., Simioni, P., Girolami, B., & Zanardi, S. (1991). The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 2(5), 673-8.
Girolami A, et al. The Role of Drugs, Particularly Oral Contraceptives, in Triggering Thrombosis in Congenital Defects of Coagulation Inhibitors: a Study of Six Patients. Blood Coagul Fibrinolysis. 1991;2(5):673-8. PubMed PMID: 1782339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients. AU - Girolami,A, AU - Simioni,P, AU - Girolami,B, AU - Zanardi,S, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez KW - Biology KW - Blood Coagulation Effects KW - Case Studies KW - Contraception KW - Contraceptive Methods KW - Developed Countries KW - Diseases KW - Embolism KW - Europe KW - Family Planning KW - Hematological Effects KW - Hemic System KW - Hereditary Diseases KW - Italy KW - Mediterranean Countries KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Physiology KW - Research Methodology KW - Research Report KW - Serum Protein Effects KW - Southern Europe KW - Studies KW - Thromboembolism KW - Thrombosis KW - Vascular Diseases SP - 673 EP - 8 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul Fibrinolysis VL - 2 IS - 5 N2 - It is well established that pregnancy and puerperium, surgery and trauma may often trigger thrombotic events even in the normal population. On the other hand, patients with congenital deficiency of clotting inhibitors may develop spontaneous thrombotic episodes, although they become often symptomatic when one of the above-mentioned triggering factors is present. We found this to be true in 40 out of 81 symptomatic patients with congenital defects of coagulation inhibitors. In six (15%) of these cases medications (mainly oral contraceptives) triggered the thrombotic event. The incidence of pharmacological factors as a cause of thrombosis is commonly maintained to be low. This study indicates that this is not so and underlines the potential importance of drugs, particularly oral contraceptives, in the pathogenesis of thrombotic events in patients with congenital defects of clotting inhibitors. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/1782339/The_role_of_drugs_particularly_oral_contraceptives_in_triggering_thrombosis_in_congenital_defects_of_coagulation_inhibitors:_a_study_of_six_patients_ DB - PRIME DP - Unbound Medicine ER -