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Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia.
Am J Clin Nutr. 2007 Sep; 86(3):790-6.AJ

Abstract

BACKGROUND

Plant sterol (PS)-enriched foods have been shown to reduce plasma LDL-cholesterol concentrations. In most studies, however, PSs were incorporated into food products of high fat content.

OBJECTIVE

We examined the effect of daily consumption of PS-supplemented low-fat fermented milk (FM) on the plasma lipid profile and on systemic oxidative stress in hypercholesterolemic subjects.

DESIGN

Hypercholesterolemic subjects (LDL-cholesterol concentrations >or=130 and <or= 190 mg/dL; n = 194) consumed 2 low-fat portions of FM in the same meal daily for 6 wk. Subjects were randomly assigned to 2 groups: low-fat FM enriched with 0.8 g PS ester per portion or control FM. Plasma concentrations of lipids, oxidized LDL, beta-carotene, beta-sitosterol, campesterol, and high-sensitivity C-reactive protein were measured during the trial.

RESULTS

Plasma LDL-cholesterol concentrations were reduced by 9.5% and 7.8% after 3 and 6 wk, respectively, in the 1.6-g/d PS group compared with the control group, whereas plasma triacylglycerol and HDL-cholesterol concentrations were not significantly affected. In addition, there were no significant changes in serum beta-carotene on normalization to LDL cholesterol during the study period in both groups, whereas plasma concentrations of oxidized LDL were reduced significantly in the PS group compared with the control group (-1.73 compared with 1.40 U/L, respectively; P < 0.05). Plasma sitosterol concentrations were increased by 35% (P < 0.001 compared with control); however, campesterol concentrations did not change during the study period.

CONCLUSION

Daily consumption of 1.6 g PS in low-fat FM efficiently lowers LDL cholesterol in subjects with moderate hypercholesterolemia without deleterious effects on biomarkers of oxidative stress.

Authors+Show Affiliations

Service d'Endocrinologie-Métabolisme, AP-HP, Hôpital de la Pitié, Paris, France. boris.hansel@psl.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17823447

Citation

Hansel, Boris, et al. "Effect of Low-fat, Fermented Milk Enriched With Plant Sterols On Serum Lipid Profile and Oxidative Stress in Moderate Hypercholesterolemia." The American Journal of Clinical Nutrition, vol. 86, no. 3, 2007, pp. 790-6.
Hansel B, Nicolle C, Lalanne F, et al. Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. Am J Clin Nutr. 2007;86(3):790-6.
Hansel, B., Nicolle, C., Lalanne, F., Tondu, F., Lassel, T., Donazzolo, Y., Ferrières, J., Krempf, M., Schlienger, J. L., Verges, B., Chapman, M. J., & Bruckert, E. (2007). Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. The American Journal of Clinical Nutrition, 86(3), 790-6.
Hansel B, et al. Effect of Low-fat, Fermented Milk Enriched With Plant Sterols On Serum Lipid Profile and Oxidative Stress in Moderate Hypercholesterolemia. Am J Clin Nutr. 2007;86(3):790-6. PubMed PMID: 17823447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. AU - Hansel,Boris, AU - Nicolle,Catherine, AU - Lalanne,Florent, AU - Tondu,Françoise, AU - Lassel,Taous, AU - Donazzolo,Yves, AU - Ferrières,Jean, AU - Krempf,Michel, AU - Schlienger,Jean-Louis, AU - Verges,Bruno, AU - Chapman,M John, AU - Bruckert,Eric, PY - 2007/9/8/pubmed PY - 2008/3/8/medline PY - 2007/9/8/entrez SP - 790 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 86 IS - 3 N2 - BACKGROUND: Plant sterol (PS)-enriched foods have been shown to reduce plasma LDL-cholesterol concentrations. In most studies, however, PSs were incorporated into food products of high fat content. OBJECTIVE: We examined the effect of daily consumption of PS-supplemented low-fat fermented milk (FM) on the plasma lipid profile and on systemic oxidative stress in hypercholesterolemic subjects. DESIGN: Hypercholesterolemic subjects (LDL-cholesterol concentrations >or=130 and <or= 190 mg/dL; n = 194) consumed 2 low-fat portions of FM in the same meal daily for 6 wk. Subjects were randomly assigned to 2 groups: low-fat FM enriched with 0.8 g PS ester per portion or control FM. Plasma concentrations of lipids, oxidized LDL, beta-carotene, beta-sitosterol, campesterol, and high-sensitivity C-reactive protein were measured during the trial. RESULTS: Plasma LDL-cholesterol concentrations were reduced by 9.5% and 7.8% after 3 and 6 wk, respectively, in the 1.6-g/d PS group compared with the control group, whereas plasma triacylglycerol and HDL-cholesterol concentrations were not significantly affected. In addition, there were no significant changes in serum beta-carotene on normalization to LDL cholesterol during the study period in both groups, whereas plasma concentrations of oxidized LDL were reduced significantly in the PS group compared with the control group (-1.73 compared with 1.40 U/L, respectively; P < 0.05). Plasma sitosterol concentrations were increased by 35% (P < 0.001 compared with control); however, campesterol concentrations did not change during the study period. CONCLUSION: Daily consumption of 1.6 g PS in low-fat FM efficiently lowers LDL cholesterol in subjects with moderate hypercholesterolemia without deleterious effects on biomarkers of oxidative stress. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17823447/Effect_of_low_fat_fermented_milk_enriched_with_plant_sterols_on_serum_lipid_profile_and_oxidative_stress_in_moderate_hypercholesterolemia_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/86.3.790 DB - PRIME DP - Unbound Medicine ER -