TY - JOUR T1 - Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin. AU - Gultekin,Fatih, AU - Hicyilmaz,Hicran, Y1 - 2007/09/07/ PY - 2007/08/01/received PY - 2007/08/22/accepted PY - 2007/9/8/pubmed PY - 2008/2/1/medline PY - 2007/9/8/entrez SP - 675 EP - 81 JF - Archives of toxicology JO - Arch Toxicol VL - 81 IS - 10 N2 - This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. SN - 0340-5761 UR - https://www.unboundmedicine.com/medline/citation/17823789/Renal_deterioration_caused_by_carcinogens_as_a_consequence_of_free_radical_mediated_tissue_damage:_a_review_of_the_protective_action_of_melatonin_ L2 - https://doi.org/10.1007/s00204-007-0242-1 DB - PRIME DP - Unbound Medicine ER -