Tags

Type your tag names separated by a space and hit enter

Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acid derivatives by capillary micellar electrokinetic chromatography.
J Sep Sci. 2007 Nov; 30(16):2748-53.JS

Abstract

A new type of chiral surfactant, sodium maleopimaric acid (SMA), was synthesized, and employed for the enantioselective micellar electrokinetic chromatographic (MEKC) separation of amino acid enantiomers derivatized with naphthalene-2,3-dicarboxaldehyde (NDA-D/L-AAs). The effect of the surfactant concentration, type and concentration of the BGE, and buffer pH on the resolution was studied, and optimized conditions were used to evaluate the ability of this new surfactant to perform chiral separations toward NDA-D/L-AAs by MEKC. Enantiomeric separations of NDA-D/L-AAs were achieved with a running buffer consisting of 100 mM borate (pH 9.5) and 20 mM SMA in a 58.5 cm length x 50 microm id capillary. Under the conditions selected, two pairs of tested amino acid enantiomers including NDA-D/L-trptophan (Trp) and NDA-D/L-kynurenine (Kyn) were resolved.

Authors+Show Affiliations

Wang H
College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, China.
Zhao S
No affiliation info available
He M
No affiliation info available
Zhao Z
No affiliation info available
Pan Y
No affiliation info available
Liang Q
No affiliation info available

MeSH

Amino AcidsBuffersChromatography, Micellar Electrokinetic CapillaryHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopySpectrophotometry, InfraredSpectrophotometry, UltravioletStereoisomerismTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17823892

Citation

Wang, Hengshan, et al. "Sodium Maleopimaric Acid as Pseudostationary Phase for Chiral Separations of Amino Acid Derivatives By Capillary Micellar Electrokinetic Chromatography." Journal of Separation Science, vol. 30, no. 16, 2007, pp. 2748-53.
Wang H, Zhao S, He M, et al. Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acid derivatives by capillary micellar electrokinetic chromatography. J Sep Sci. 2007;30(16):2748-53.
Wang, H., Zhao, S., He, M., Zhao, Z., Pan, Y., & Liang, Q. (2007). Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acid derivatives by capillary micellar electrokinetic chromatography. Journal of Separation Science, 30(16), 2748-53.
Wang H, et al. Sodium Maleopimaric Acid as Pseudostationary Phase for Chiral Separations of Amino Acid Derivatives By Capillary Micellar Electrokinetic Chromatography. J Sep Sci. 2007;30(16):2748-53. PubMed PMID: 17823892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acid derivatives by capillary micellar electrokinetic chromatography. AU - Wang,Hengshan, AU - Zhao,Shulin, AU - He,Min, AU - Zhao,Zhicai, AU - Pan,Yingming, AU - Liang,Qian, PY - 2007/9/8/pubmed PY - 2008/1/8/medline PY - 2007/9/8/entrez SP - 2748 EP - 53 JF - Journal of separation science JO - J Sep Sci VL - 30 IS - 16 N2 - A new type of chiral surfactant, sodium maleopimaric acid (SMA), was synthesized, and employed for the enantioselective micellar electrokinetic chromatographic (MEKC) separation of amino acid enantiomers derivatized with naphthalene-2,3-dicarboxaldehyde (NDA-D/L-AAs). The effect of the surfactant concentration, type and concentration of the BGE, and buffer pH on the resolution was studied, and optimized conditions were used to evaluate the ability of this new surfactant to perform chiral separations toward NDA-D/L-AAs by MEKC. Enantiomeric separations of NDA-D/L-AAs were achieved with a running buffer consisting of 100 mM borate (pH 9.5) and 20 mM SMA in a 58.5 cm length x 50 microm id capillary. Under the conditions selected, two pairs of tested amino acid enantiomers including NDA-D/L-trptophan (Trp) and NDA-D/L-kynurenine (Kyn) were resolved. SN - 1615-9306 UR - https://www.unboundmedicine.com/medline/citation/17823892/Sodium_maleopimaric_acid_as_pseudostationary_phase_for_chiral_separations_of_amino_acid_derivatives_by_capillary_micellar_electrokinetic_chromatography_ L2 - https://doi.org/10.1002/jssc.200700128 DB - PRIME DP - Unbound Medicine ER -