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[Serum homocysteine, folate and vitamin B12 in venezuelan elderly].
Arch Latinoam Nutr. 2007 Mar; 57(1):26-32.AL

Abstract

The anatomical and physiological changes of aging make elderly people a vulnerable group to malnutrition and specific deficiencies of nutrients such as vitamin B12 and folate. This study was aimed to establish relationships among serum vitamin B12, folate, homocysteine concentrations and dietary intake and adequacy. Fifty five male and female elderly (60 and more years), free-living, were assessed. Measurements were: serum vitamin B12 and folate by radioimmunoanalysis (RIA), homocysteine by polarized fluorescence immunoassay, nutrient intake by three 24 hours recalls and food frequency questionnaire. Nutritional status was determined by Body Mass Index (BMI). Serum vitamin B12 and folate were at normal range (423,3+/-227,6 pmol/l and 6,4 +/- 4,5 mg/ml), but 17,5% of elderly had B12 deficiency and 12% had folate deficiency. Serum homocysteine was higher than reference values (15,8+/-4,4 mmol/l), but 47,5% showed concentrations above 15 mmol/L, male population showed higher mean value (p: 0,01). Nutrient intake was inadequate by deficiency. BMI indicated 11,8% of undernutrition, 29,4% of overweight and 20,6% of obesity A negative and inverse correlation between homocysteine and serum folate was found. Results suggest a biochemical deficiency of B12 and folate that is expressed as elevated homocysteine levels. These finding represent a high cardiovascular risk factor for this elderly group.

Authors+Show Affiliations

Centro de Investigaciones en Nutrición, Facultad de Ciencias de la Salud, (CEINUT), Universidad de Carabobo, Valencia, Venezuela.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

17824196

Citation

Meertens, Lesbia, et al. "[Serum Homocysteine, Folate and Vitamin B12 in Venezuelan Elderly]." Archivos Latinoamericanos De Nutricion, vol. 57, no. 1, 2007, pp. 26-32.
Meertens L, Díaz N, Solano L, et al. [Serum homocysteine, folate and vitamin B12 in venezuelan elderly]. Arch Latinoam Nutr. 2007;57(1):26-32.
Meertens, L., Díaz, N., Solano, L., Baron, M. A., & Rodríguez, A. (2007). [Serum homocysteine, folate and vitamin B12 in venezuelan elderly]. Archivos Latinoamericanos De Nutricion, 57(1), 26-32.
Meertens L, et al. [Serum Homocysteine, Folate and Vitamin B12 in Venezuelan Elderly]. Arch Latinoam Nutr. 2007;57(1):26-32. PubMed PMID: 17824196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum homocysteine, folate and vitamin B12 in venezuelan elderly]. AU - Meertens,Lesbia, AU - Díaz,Nayka, AU - Solano,Liseti, AU - Baron,Maria Adela, AU - Rodríguez,Adelmo, PY - 2007/9/11/pubmed PY - 2008/1/31/medline PY - 2007/9/11/entrez SP - 26 EP - 32 JF - Archivos latinoamericanos de nutricion JO - Arch Latinoam Nutr VL - 57 IS - 1 N2 - The anatomical and physiological changes of aging make elderly people a vulnerable group to malnutrition and specific deficiencies of nutrients such as vitamin B12 and folate. This study was aimed to establish relationships among serum vitamin B12, folate, homocysteine concentrations and dietary intake and adequacy. Fifty five male and female elderly (60 and more years), free-living, were assessed. Measurements were: serum vitamin B12 and folate by radioimmunoanalysis (RIA), homocysteine by polarized fluorescence immunoassay, nutrient intake by three 24 hours recalls and food frequency questionnaire. Nutritional status was determined by Body Mass Index (BMI). Serum vitamin B12 and folate were at normal range (423,3+/-227,6 pmol/l and 6,4 +/- 4,5 mg/ml), but 17,5% of elderly had B12 deficiency and 12% had folate deficiency. Serum homocysteine was higher than reference values (15,8+/-4,4 mmol/l), but 47,5% showed concentrations above 15 mmol/L, male population showed higher mean value (p: 0,01). Nutrient intake was inadequate by deficiency. BMI indicated 11,8% of undernutrition, 29,4% of overweight and 20,6% of obesity A negative and inverse correlation between homocysteine and serum folate was found. Results suggest a biochemical deficiency of B12 and folate that is expressed as elevated homocysteine levels. These finding represent a high cardiovascular risk factor for this elderly group. SN - 0004-0622 UR - https://www.unboundmedicine.com/medline/citation/17824196/[Serum_homocysteine_folate_and_vitamin_B12_in_venezuelan_elderly]_ L2 - https://medlineplus.gov/folicacid.html DB - PRIME DP - Unbound Medicine ER -