Tags

Type your tag names separated by a space and hit enter

Effect of blood pressure on L-NAME-sensitive component of vasorelaxation in adult rats.
Physiol Res. 2007; 56 Suppl 2:S77-S84.PR

Abstract

The aim of this study was to investigate nitric oxide (NO) production and L-NAME-sensitive component of endothelium-dependent vasorelaxation in adult normotensive Wistar-Kyoto rats (WKY), borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR). Blood pressure (BP) of WKY, BHR and SHR (determined by tail-cuff) was 111+/-3, 140+/-4 and 184+/-6 mm Hg, respectively. NO synthase activity (determined by conversion of [(3)H]-L-arginine) was significantly higher in the aorta of BHR and SHR vs. WKY and in the left ventricle of SHR vs. both BHR and WKY. L-NAME-sensitive component of endothelium-dependent relaxation was investigated in the preconstricted femoral arteries using the wire myograph during isometric conditions as a difference between acetylcholine-induced relaxation before and after acute N(G)-nitro-L-arginine methyl ester pre-treatment (L-NAME, 10(-5) mol/l). Acetylcholine-induced vasorelaxation of SHR was significantly greater than that in WKY. L-NAME-sensitive component of vasorelaxation in WKY, BHR and SHR was 20+/-3 %, 29+/-4 % (p<0.05 vs. WKY) and 37+/-3 % (p<0.05 vs. BHR), respectively. There was a significant positive correlation between BP and L-NAME-sensitive component of relaxation of the femoral artery. In conclusion, results suggest the absence of endothelial dysfunction in the femoral artery of adult borderline and spontaneously hypertensive rats and gradual elevation of L-NAME-sensitive component of vasorelaxation with increasing blood pressure.

Authors+Show Affiliations

Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17824803

Citation

Púzserová, A, et al. "Effect of Blood Pressure On L-NAME-sensitive Component of Vasorelaxation in Adult Rats." Physiological Research, vol. 56 Suppl 2, 2007, pp. S77-S84.
Púzserová A, Csizmadiová Z, Bernátová I. Effect of blood pressure on L-NAME-sensitive component of vasorelaxation in adult rats. Physiol Res. 2007;56 Suppl 2:S77-S84.
Púzserová, A., Csizmadiová, Z., & Bernátová, I. (2007). Effect of blood pressure on L-NAME-sensitive component of vasorelaxation in adult rats. Physiological Research, 56 Suppl 2, S77-S84.
Púzserová A, Csizmadiová Z, Bernátová I. Effect of Blood Pressure On L-NAME-sensitive Component of Vasorelaxation in Adult Rats. Physiol Res. 2007;56 Suppl 2:S77-S84. PubMed PMID: 17824803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of blood pressure on L-NAME-sensitive component of vasorelaxation in adult rats. AU - Púzserová,A, AU - Csizmadiová,Z, AU - Bernátová,I, Y1 - 2007/09/05/ PY - 2007/9/11/pubmed PY - 2008/4/18/medline PY - 2007/9/11/entrez SP - S77 EP - S84 JF - Physiological research JO - Physiol Res VL - 56 Suppl 2 N2 - The aim of this study was to investigate nitric oxide (NO) production and L-NAME-sensitive component of endothelium-dependent vasorelaxation in adult normotensive Wistar-Kyoto rats (WKY), borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR). Blood pressure (BP) of WKY, BHR and SHR (determined by tail-cuff) was 111+/-3, 140+/-4 and 184+/-6 mm Hg, respectively. NO synthase activity (determined by conversion of [(3)H]-L-arginine) was significantly higher in the aorta of BHR and SHR vs. WKY and in the left ventricle of SHR vs. both BHR and WKY. L-NAME-sensitive component of endothelium-dependent relaxation was investigated in the preconstricted femoral arteries using the wire myograph during isometric conditions as a difference between acetylcholine-induced relaxation before and after acute N(G)-nitro-L-arginine methyl ester pre-treatment (L-NAME, 10(-5) mol/l). Acetylcholine-induced vasorelaxation of SHR was significantly greater than that in WKY. L-NAME-sensitive component of vasorelaxation in WKY, BHR and SHR was 20+/-3 %, 29+/-4 % (p<0.05 vs. WKY) and 37+/-3 % (p<0.05 vs. BHR), respectively. There was a significant positive correlation between BP and L-NAME-sensitive component of relaxation of the femoral artery. In conclusion, results suggest the absence of endothelial dysfunction in the femoral artery of adult borderline and spontaneously hypertensive rats and gradual elevation of L-NAME-sensitive component of vasorelaxation with increasing blood pressure. SN - 0862-8408 UR - https://www.unboundmedicine.com/medline/citation/17824803/Effect_of_blood_pressure_on_L_NAME_sensitive_component_of_vasorelaxation_in_adult_rats_ L2 - http://www.biomed.cas.cz/physiolres/pdf/56 Suppl 2/56_S77.pdf DB - PRIME DP - Unbound Medicine ER -