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Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation.
Int J Lab Hematol. 2007 Oct; 29(5):341-6.IJ

Abstract

Ferritin concentration, as a parameter of iron status that is commonly used in the diagnosis of iron deficiency anaemia (IDA), often has limited values if the iron deficiency is accompanied by inflammatory disease. This study evaluated the value of reticulocyte haemoglobin content (CHr) and soluble transferrin receptor-ferritin index (sTfR/F) in the diagnosis of IDA and differential diagnosis of IDA and anaemia of chronic disease. The study included 66 nonanaemic individuals as controls, 86 patients with IDA divided into noninflammatory and inflammatory subgroups, and 32 patients with anaemia of chronic disease. Blood count, iron, transferrin saturation, total iron binding capacity, ferritin, C-reactive protein, sTfR and CHr were determined. Receiver operator characteristic curve analysis showed very high discriminating power for CHr, soluble transferrin receptor (sTfR) and sTfR/F in the diagnosis of IDA. In patients with anaemia of chronic disease these parameters showed no significant difference from the control. CHr and sTfR enabled recognition of iron deficiency and were not affected by acute phase reaction. They are sensitive markers of body iron status with additional value to conventional tests for the detection of iron deficiency.

Authors+Show Affiliations

Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia. mmarica@net.yuNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17824914

Citation

Marković, M, et al. "Reticulocyte Haemoglobin Content Vs. Soluble Transferrin Receptor and Ferritin Index in Iron Deficiency Anaemia Accompanied With Inflammation." International Journal of Laboratory Hematology, vol. 29, no. 5, 2007, pp. 341-6.
Marković M, Majkić-Singh N, Ignjatović S, et al. Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation. Int J Lab Hematol. 2007;29(5):341-6.
Marković, M., Majkić-Singh, N., Ignjatović, S., & Singh, S. (2007). Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation. International Journal of Laboratory Hematology, 29(5), 341-6.
Marković M, et al. Reticulocyte Haemoglobin Content Vs. Soluble Transferrin Receptor and Ferritin Index in Iron Deficiency Anaemia Accompanied With Inflammation. Int J Lab Hematol. 2007;29(5):341-6. PubMed PMID: 17824914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation. AU - Marković,M, AU - Majkić-Singh,N, AU - Ignjatović,S, AU - Singh,S, PY - 2007/9/11/pubmed PY - 2007/10/31/medline PY - 2007/9/11/entrez SP - 341 EP - 6 JF - International journal of laboratory hematology JO - Int J Lab Hematol VL - 29 IS - 5 N2 - Ferritin concentration, as a parameter of iron status that is commonly used in the diagnosis of iron deficiency anaemia (IDA), often has limited values if the iron deficiency is accompanied by inflammatory disease. This study evaluated the value of reticulocyte haemoglobin content (CHr) and soluble transferrin receptor-ferritin index (sTfR/F) in the diagnosis of IDA and differential diagnosis of IDA and anaemia of chronic disease. The study included 66 nonanaemic individuals as controls, 86 patients with IDA divided into noninflammatory and inflammatory subgroups, and 32 patients with anaemia of chronic disease. Blood count, iron, transferrin saturation, total iron binding capacity, ferritin, C-reactive protein, sTfR and CHr were determined. Receiver operator characteristic curve analysis showed very high discriminating power for CHr, soluble transferrin receptor (sTfR) and sTfR/F in the diagnosis of IDA. In patients with anaemia of chronic disease these parameters showed no significant difference from the control. CHr and sTfR enabled recognition of iron deficiency and were not affected by acute phase reaction. They are sensitive markers of body iron status with additional value to conventional tests for the detection of iron deficiency. SN - 1751-5521 UR - https://www.unboundmedicine.com/medline/citation/17824914/Reticulocyte_haemoglobin_content_vs__soluble_transferrin_receptor_and_ferritin_index_in_iron_deficiency_anaemia_accompanied_with_inflammation_ L2 - https://doi.org/10.1111/j.1365-2257.2006.00875.x DB - PRIME DP - Unbound Medicine ER -