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The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts.
FEBS J. 2007 Sep; 274(18):4802-11.FJ

Abstract

Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation.

Authors+Show Affiliations

Biochemistry and Molecular Biology Department, Biology Faculty, University of Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17824958

Citation

Lizarraga, D, et al. "The Importance of Polymerization and Galloylation for the Antiproliferative Properties of Procyanidin-rich Natural Extracts." The FEBS Journal, vol. 274, no. 18, 2007, pp. 4802-11.
Lizarraga D, Lozano C, Briedé JJ, et al. The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. FEBS J. 2007;274(18):4802-11.
Lizarraga, D., Lozano, C., Briedé, J. J., van Delft, J. H., Touriño, S., Centelles, J. J., Torres, J. L., & Cascante, M. (2007). The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. The FEBS Journal, 274(18), 4802-11.
Lizarraga D, et al. The Importance of Polymerization and Galloylation for the Antiproliferative Properties of Procyanidin-rich Natural Extracts. FEBS J. 2007;274(18):4802-11. PubMed PMID: 17824958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. AU - Lizarraga,D, AU - Lozano,C, AU - Briedé,J J, AU - van Delft,J H, AU - Touriño,S, AU - Centelles,J J, AU - Torres,J L, AU - Cascante,M, PY - 2007/9/11/pubmed PY - 2007/12/13/medline PY - 2007/9/11/entrez SP - 4802 EP - 11 JF - The FEBS journal JO - FEBS J VL - 274 IS - 18 N2 - Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation. SN - 1742-464X UR - https://www.unboundmedicine.com/medline/citation/17824958/The_importance_of_polymerization_and_galloylation_for_the_antiproliferative_properties_of_procyanidin_rich_natural_extracts_ DB - PRIME DP - Unbound Medicine ER -