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Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations.
Clin Chim Acta. 2007 Nov-Dec; 386(1-2):69-75.CC

Abstract

BACKGROUND

Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women.

METHODS

One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women.

RESULTS

Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r=0.404, p<0.0001 and r=0.348, p<0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r=-0.222, p=0.0051 and r=-0.334, p<0.0001, respectively) and women (r=-0.281, p=0.0014 and r=-0.251, p=0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index.

CONCLUSION

Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.

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Authors+Show Affiliations

Yasui T
Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
Tomita J
No affiliation info available
Miyatani Y
No affiliation info available
Yamada M
No affiliation info available
Uemura H
No affiliation info available
Irahara M
No affiliation info available
Arai M
No affiliation info available
Kojimahara N
No affiliation info available
Okabe R
No affiliation info available
Ishii Y
No affiliation info available
Tashiro S
No affiliation info available
Sato H
No affiliation info available

MeSH

AdiponectinAgedAged, 80 and overAgingBody Mass IndexFemaleHomeostasisHumansInsulin ResistanceMaleMetabolic SyndromeMiddle AgedModels, BiologicalRegression AnalysisRisk AssessmentSex FactorsSex Hormone-Binding GlobulinTestosterone

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17825805

Citation

Yasui, Toshiyuki, et al. "Associations of Adiponectin With Sex Hormone-binding Globulin Levels in Aging Male and Female Populations." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 386, no. 1-2, 2007, pp. 69-75.
Yasui T, Tomita J, Miyatani Y, et al. Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. Clin Chim Acta. 2007;386(1-2):69-75.
Yasui, T., Tomita, J., Miyatani, Y., Yamada, M., Uemura, H., Irahara, M., Arai, M., Kojimahara, N., Okabe, R., Ishii, Y., Tashiro, S., & Sato, H. (2007). Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. Clinica Chimica Acta; International Journal of Clinical Chemistry, 386(1-2), 69-75.
Yasui T, et al. Associations of Adiponectin With Sex Hormone-binding Globulin Levels in Aging Male and Female Populations. Clin Chim Acta. 2007 Nov-Dec;386(1-2):69-75. PubMed PMID: 17825805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. AU - Yasui,Toshiyuki, AU - Tomita,Junko, AU - Miyatani,Yuka, AU - Yamada,Masayo, AU - Uemura,Hirokazu, AU - Irahara,Minoru, AU - Arai,Makoto, AU - Kojimahara,Noriko, AU - Okabe,Ryugo, AU - Ishii,Yasutomo, AU - Tashiro,Shin-ichi, AU - Sato,Hiroshi, Y1 - 2007/08/14/ PY - 2007/06/21/received PY - 2007/07/19/revised PY - 2007/08/06/accepted PY - 2007/9/11/pubmed PY - 2008/1/10/medline PY - 2007/9/11/entrez SP - 69 EP - 75 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 386 IS - 1-2 N2 - BACKGROUND: Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women. METHODS: One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women. RESULTS: Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r=0.404, p<0.0001 and r=0.348, p<0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r=-0.222, p=0.0051 and r=-0.334, p<0.0001, respectively) and women (r=-0.281, p=0.0014 and r=-0.251, p=0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index. CONCLUSION: Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/17825805/Associations_of_adiponectin_with_sex_hormone_binding_globulin_levels_in_aging_male_and_female_populations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(07)00393-2 DB - PRIME DP - Unbound Medicine ER -