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Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity.
FEBS Lett. 2007 Oct 02; 581(24):4621-6.FL

Abstract

Recent studies suggest that sphingosine 1-phosphate (S1P) protects against atherosclerosis. We assessed the effects of S1P on monocyte-endothelial interaction in the presence of inflammatory mediators. Pretreatment of THP-1 cells with S1P abolished Phorbol 12 myristate 13-acetate (PMA)-induced THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). S1P inhibited PMA-induced activation of RhoA, but not PKCs. S1P activated p190Rho GTPase activation protein (GAP) only in the presence of PMA, suggesting an inhibitory effect of S1P and PMA to suppress RhoA. In conclusion, S1P inhibited monocyte-endothelial interactions by inhibiting RhoA activity which may explain its anti-atherogenic effects.

Authors+Show Affiliations

Bioethics Research Center, Tokyo Medical and Dental University, 1-5-45, Yushima, Bldg. D-809, Bunkyo-ku, Tokyo 113-8519, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17825823

Citation

Tani, Mariko, et al. "Sphingosine 1-phosphate (S1P) Inhibits Monocyte-endothelial Cell Interaction By Regulating of RhoA Activity." FEBS Letters, vol. 581, no. 24, 2007, pp. 4621-6.
Tani M, Kawakami A, Nagai M, et al. Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. FEBS Lett. 2007;581(24):4621-6.
Tani, M., Kawakami, A., Nagai, M., Shimokado, K., Kondo, K., & Yoshida, M. (2007). Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. FEBS Letters, 581(24), 4621-6.
Tani M, et al. Sphingosine 1-phosphate (S1P) Inhibits Monocyte-endothelial Cell Interaction By Regulating of RhoA Activity. FEBS Lett. 2007 Oct 2;581(24):4621-6. PubMed PMID: 17825823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. AU - Tani,Mariko, AU - Kawakami,Akio, AU - Nagai,Miyuzu, AU - Shimokado,Kentaro, AU - Kondo,Kazuo, AU - Yoshida,Masayuki, Y1 - 2007/08/31/ PY - 2007/05/31/received PY - 2007/08/03/revised PY - 2007/08/03/accepted PY - 2007/9/11/pubmed PY - 2007/12/6/medline PY - 2007/9/11/entrez SP - 4621 EP - 6 JF - FEBS letters JO - FEBS Lett VL - 581 IS - 24 N2 - Recent studies suggest that sphingosine 1-phosphate (S1P) protects against atherosclerosis. We assessed the effects of S1P on monocyte-endothelial interaction in the presence of inflammatory mediators. Pretreatment of THP-1 cells with S1P abolished Phorbol 12 myristate 13-acetate (PMA)-induced THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). S1P inhibited PMA-induced activation of RhoA, but not PKCs. S1P activated p190Rho GTPase activation protein (GAP) only in the presence of PMA, suggesting an inhibitory effect of S1P and PMA to suppress RhoA. In conclusion, S1P inhibited monocyte-endothelial interactions by inhibiting RhoA activity which may explain its anti-atherogenic effects. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/17825823/Sphingosine_1_phosphate__S1P__inhibits_monocyte_endothelial_cell_interaction_by_regulating_of_RhoA_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(07)00929-5 DB - PRIME DP - Unbound Medicine ER -