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Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years.
Am J Cardiol 2007; 100(6):981-5AJ

Abstract

Measurement of coronary artery calcium (CAC) has been proposed as a screening tool, but CAC levels may differ according to race and gender. Racial/ethnic and gender distributions of CAC were examined in a randomly selected cohort of 60- to 69-year-old healthy subjects. Demographic, race/ethnicity (R/E), and clinical characteristics and assessment of CAC were collected. There were 723 white/European, 105 African-American, 73 Hispanic, and 67 East Asian subjects (597 men, 369 women) included in this analysis. Men had a significantly higher prevalence of any CAC (score>10) than women (76% vs 41%; p<0.0001). For men, the unadjusted odds of having any CAC was 2.2 (95% confidence interval [CI] 1.3 to 3.8) for whites compared with African-Americans. For women, CAC scores were not significantly different across ethnic groups. After adjustment for coronary risk factors, African-American and East Asian R/E remained associated with a lower prevalence of CAC in men (adjusted odds ratios [ORs] 0.33 and 0.47, respectively), as well as older age (OR 1.2, 95% CI 1.1 to 1.3), known hyperlipidemia (OR 1.7, 95% CI 1.1 to 2.7), and history of hypertension (OR 2.2, 95% CI 1.4 to 3.3). In women, Asian R/E (OR 2.5, 95% CI 1.1 to 5.7), history of smoking (adjusted OR 2.8, 95% CI 1.3 to 6.1), and known hyperlipidemia (adjusted OR 2.0, 95% CI 1.3 to 3.1) were associated with a higher prevalence of CAC independent of other risk factors. In conclusion, our data indicate that the presence of CAC varied significantly across selected race/ethnic groups independent of traditional cardiovascular risk factors.

Authors+Show Affiliations

Stanford Prevention Research Center, Stanford University, Department of Radiology, Stanford, California, USA. jfair@stanford.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17826382

Citation

Fair, Joan M., et al. "Ethnic Differences in Coronary Artery Calcium in a Healthy Cohort Aged 60 to 69 Years." The American Journal of Cardiology, vol. 100, no. 6, 2007, pp. 981-5.
Fair JM, Kiazand A, Varady A, et al. Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years. Am J Cardiol. 2007;100(6):981-5.
Fair, J. M., Kiazand, A., Varady, A., Mahbouba, M., Norton, L., Rubin, G. D., ... Fortmann, S. P. (2007). Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years. The American Journal of Cardiology, 100(6), pp. 981-5.
Fair JM, et al. Ethnic Differences in Coronary Artery Calcium in a Healthy Cohort Aged 60 to 69 Years. Am J Cardiol. 2007 Sep 15;100(6):981-5. PubMed PMID: 17826382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years. AU - Fair,Joan M, AU - Kiazand,Alexandre, AU - Varady,Ann, AU - Mahbouba,Mohammed, AU - Norton,Linda, AU - Rubin,Geoffrey D, AU - Iribarren,Carlos, AU - Go,Alan S, AU - Hlatky,Mark A, AU - Fortmann,Stephen P, Y1 - 2007/07/02/ PY - 2007/01/20/received PY - 2007/04/04/revised PY - 2007/04/13/accepted PY - 2007/9/11/pubmed PY - 2007/11/2/medline PY - 2007/9/11/entrez SP - 981 EP - 5 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 100 IS - 6 N2 - Measurement of coronary artery calcium (CAC) has been proposed as a screening tool, but CAC levels may differ according to race and gender. Racial/ethnic and gender distributions of CAC were examined in a randomly selected cohort of 60- to 69-year-old healthy subjects. Demographic, race/ethnicity (R/E), and clinical characteristics and assessment of CAC were collected. There were 723 white/European, 105 African-American, 73 Hispanic, and 67 East Asian subjects (597 men, 369 women) included in this analysis. Men had a significantly higher prevalence of any CAC (score>10) than women (76% vs 41%; p<0.0001). For men, the unadjusted odds of having any CAC was 2.2 (95% confidence interval [CI] 1.3 to 3.8) for whites compared with African-Americans. For women, CAC scores were not significantly different across ethnic groups. After adjustment for coronary risk factors, African-American and East Asian R/E remained associated with a lower prevalence of CAC in men (adjusted odds ratios [ORs] 0.33 and 0.47, respectively), as well as older age (OR 1.2, 95% CI 1.1 to 1.3), known hyperlipidemia (OR 1.7, 95% CI 1.1 to 2.7), and history of hypertension (OR 2.2, 95% CI 1.4 to 3.3). In women, Asian R/E (OR 2.5, 95% CI 1.1 to 5.7), history of smoking (adjusted OR 2.8, 95% CI 1.3 to 6.1), and known hyperlipidemia (adjusted OR 2.0, 95% CI 1.3 to 3.1) were associated with a higher prevalence of CAC independent of other risk factors. In conclusion, our data indicate that the presence of CAC varied significantly across selected race/ethnic groups independent of traditional cardiovascular risk factors. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17826382/Ethnic_differences_in_coronary_artery_calcium_in_a_healthy_cohort_aged_60_to_69_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(07)01138-1 DB - PRIME DP - Unbound Medicine ER -