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Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate.
Eur J Pharm Sci. 2007 Nov; 32(3):216-22.EJ

Abstract

The aim of the present paper was the use of mesoporous silicate MCM-41 to increase the dissolution rate of piroxicam, a non-steroidal anti-inflammatory drug-class II of the Biopharmaceutic Classification System. The inclusion/adsorption compound of piroxicam in MCM-41 was obtained with a drug loading of about 14%. X-ray powder diffraction and differential scanning calorimetry (DSC) revealed the presence of piroxicam not arranged in crystalline form and FT-IR spectroscopy showed the presence of light interactions (hydrogen bonds) between the silicate silanols and the drug. The decrease of Brunauer, Emmett and Teller (B.E.T.) specific surface area and pore volume between free MCM-41 and the inclusion/adsorption compound was a prove of the presence of piroxicam inside the mesopores. The inclusion compound was submitted to in vitro dissolution tests and a remarkable dissolution rate improvement was observed in comparison to the crystalline drug in all tested conditions. The dissolution profile at pH 1.2 was comparable to that of the marketed product Brexin, a formulation with rapid analgesic effect onset. The improvement of dissolution rate is due to both the lack of drug in the crystalline form and to the extremely large surface area of the siliceous support. Physical stability tests of the free drug and the inclusion/adsorption complex were conducted as well over one month storage at 40 degrees C at different relative humidity.

Authors+Show Affiliations

Dipartimento di Chimica e Tecnologia del Farmaco, Via del liceo 1, Perugia, Italy. valeria.ambrogi@unipg.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17826966

Citation

Ambrogi, V, et al. "Improvement of Dissolution Rate of Piroxicam By Inclusion Into MCM-41 Mesoporous Silicate." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 32, no. 3, 2007, pp. 216-22.
Ambrogi V, Perioli L, Marmottini F, et al. Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate. Eur J Pharm Sci. 2007;32(3):216-22.
Ambrogi, V., Perioli, L., Marmottini, F., Giovagnoli, S., Esposito, M., & Rossi, C. (2007). Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 32(3), 216-22.
Ambrogi V, et al. Improvement of Dissolution Rate of Piroxicam By Inclusion Into MCM-41 Mesoporous Silicate. Eur J Pharm Sci. 2007;32(3):216-22. PubMed PMID: 17826966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate. AU - Ambrogi,V, AU - Perioli,L, AU - Marmottini,F, AU - Giovagnoli,S, AU - Esposito,M, AU - Rossi,C, Y1 - 2007/08/06/ PY - 2007/06/08/received PY - 2007/07/26/revised PY - 2007/07/30/accepted PY - 2007/9/11/pubmed PY - 2007/12/21/medline PY - 2007/9/11/entrez SP - 216 EP - 22 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 32 IS - 3 N2 - The aim of the present paper was the use of mesoporous silicate MCM-41 to increase the dissolution rate of piroxicam, a non-steroidal anti-inflammatory drug-class II of the Biopharmaceutic Classification System. The inclusion/adsorption compound of piroxicam in MCM-41 was obtained with a drug loading of about 14%. X-ray powder diffraction and differential scanning calorimetry (DSC) revealed the presence of piroxicam not arranged in crystalline form and FT-IR spectroscopy showed the presence of light interactions (hydrogen bonds) between the silicate silanols and the drug. The decrease of Brunauer, Emmett and Teller (B.E.T.) specific surface area and pore volume between free MCM-41 and the inclusion/adsorption compound was a prove of the presence of piroxicam inside the mesopores. The inclusion compound was submitted to in vitro dissolution tests and a remarkable dissolution rate improvement was observed in comparison to the crystalline drug in all tested conditions. The dissolution profile at pH 1.2 was comparable to that of the marketed product Brexin, a formulation with rapid analgesic effect onset. The improvement of dissolution rate is due to both the lack of drug in the crystalline form and to the extremely large surface area of the siliceous support. Physical stability tests of the free drug and the inclusion/adsorption complex were conducted as well over one month storage at 40 degrees C at different relative humidity. SN - 0928-0987 UR - https://www.unboundmedicine.com/medline/citation/17826966/Improvement_of_dissolution_rate_of_piroxicam_by_inclusion_into_MCM_41_mesoporous_silicate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(07)00323-5 DB - PRIME DP - Unbound Medicine ER -