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Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.
Biol Pharm Bull. 2007 Sep; 30(9):1732-9.BP

Abstract

This study aimed to investigate the mechanism underlying the protective effects of manganese complexes of curcumin (Cp-Mn) and diacetylcurcumin (DiAc-Cp-Mn) on kainic acid (KA)-induced excitotoxicity in the rat hippocampus. Systemic injection of KA (10 mg/kg, i.p.) caused seizures and increased the expression of neurotoxic markers, immediate early genes [c-jun, cyclooxygenase 2 (COX-2), brain-derived neurotrophic factor (BDNF), and heat shock protein 70 (hsp70)] and a delayed response gene [inducible nitric oxide synthase (iNOS)], which were measured at 6 and 72 h after KA injection, respectively, in the hippocampus. Pretreatment with Cp-Mn (50 mg/kg, i.p.) and DiAc-Cp-Mn (50 mg/kg, i.p.) but not with curcumin (50 mg/kg, i.p.) delayed the onset of KA-induced seizure without affecting the seizure score. KA injection induced c-Fos immunoreactivity in DG, CA1, and CA3 hippocampal regions, the expression of which peaked at 6 h after injection. Cp-Mn and DiAc-Cp-Mn treatment significantly decreased c-Fos expression elicited by KA. Moreover, Cp-Mn and DiAc-Cp-Mn administration suppressed the KA-induced expression of c-jun, COX-2, BDNF, and iNOS mRNA, whereas curcumin attenuated only iNOS mRNA expression. No compounds tested had an effect on KA-induced hsp70 expression. It is therefore likely that in addition to radical scavenging and SOD-like activities, the suppression of potential neuronal injury marker expression by Cp-Mn and DiAc-Cp-Mn, contributes to the neuroprotective activities of these compounds, which are superior to those of curcumin, on KA-induced excitotoxicity in the hippocampus. These results suggest the beneficial effects of Cp-Mn, and DiAc-Cp-Mn on the treatment of excitotoxicity-induced neurodegenerative diseases.

Authors+Show Affiliations

Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17827730

Citation

Sumanont, Yaowared, et al. "Effects of Manganese Complexes of Curcumin and Diacetylcurcumin On Kainic Acid-induced Neurotoxic Responses in the Rat Hippocampus." Biological & Pharmaceutical Bulletin, vol. 30, no. 9, 2007, pp. 1732-9.
Sumanont Y, Murakami Y, Tohda M, et al. Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biol Pharm Bull. 2007;30(9):1732-9.
Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., & Matsumoto, K. (2007). Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biological & Pharmaceutical Bulletin, 30(9), 1732-9.
Sumanont Y, et al. Effects of Manganese Complexes of Curcumin and Diacetylcurcumin On Kainic Acid-induced Neurotoxic Responses in the Rat Hippocampus. Biol Pharm Bull. 2007;30(9):1732-9. PubMed PMID: 17827730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. AU - Sumanont,Yaowared, AU - Murakami,Yukihisa, AU - Tohda,Michihisa, AU - Vajragupta,Opa, AU - Watanabe,Hiroshi, AU - Matsumoto,Kinzo, PY - 2007/9/11/pubmed PY - 2007/10/13/medline PY - 2007/9/11/entrez SP - 1732 EP - 9 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 30 IS - 9 N2 - This study aimed to investigate the mechanism underlying the protective effects of manganese complexes of curcumin (Cp-Mn) and diacetylcurcumin (DiAc-Cp-Mn) on kainic acid (KA)-induced excitotoxicity in the rat hippocampus. Systemic injection of KA (10 mg/kg, i.p.) caused seizures and increased the expression of neurotoxic markers, immediate early genes [c-jun, cyclooxygenase 2 (COX-2), brain-derived neurotrophic factor (BDNF), and heat shock protein 70 (hsp70)] and a delayed response gene [inducible nitric oxide synthase (iNOS)], which were measured at 6 and 72 h after KA injection, respectively, in the hippocampus. Pretreatment with Cp-Mn (50 mg/kg, i.p.) and DiAc-Cp-Mn (50 mg/kg, i.p.) but not with curcumin (50 mg/kg, i.p.) delayed the onset of KA-induced seizure without affecting the seizure score. KA injection induced c-Fos immunoreactivity in DG, CA1, and CA3 hippocampal regions, the expression of which peaked at 6 h after injection. Cp-Mn and DiAc-Cp-Mn treatment significantly decreased c-Fos expression elicited by KA. Moreover, Cp-Mn and DiAc-Cp-Mn administration suppressed the KA-induced expression of c-jun, COX-2, BDNF, and iNOS mRNA, whereas curcumin attenuated only iNOS mRNA expression. No compounds tested had an effect on KA-induced hsp70 expression. It is therefore likely that in addition to radical scavenging and SOD-like activities, the suppression of potential neuronal injury marker expression by Cp-Mn and DiAc-Cp-Mn, contributes to the neuroprotective activities of these compounds, which are superior to those of curcumin, on KA-induced excitotoxicity in the hippocampus. These results suggest the beneficial effects of Cp-Mn, and DiAc-Cp-Mn on the treatment of excitotoxicity-induced neurodegenerative diseases. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/17827730/Effects_of_manganese_complexes_of_curcumin_and_diacetylcurcumin_on_kainic_acid_induced_neurotoxic_responses_in_the_rat_hippocampus_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/30.1732?from=PubMed DB - PRIME DP - Unbound Medicine ER -