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Multichannel intraluminal impedance and pH-metry for investigation of symptomatic gastroesophageal reflux disease.
Dig Dis 2007; 25(3):179-82DD

Abstract

BACKGROUND

Combined multichannel intraluminal impedance and pH-metry (MII-pH) is a technique that enables monitoring of gastroesophageal reflux independent of its acidity.

AIM

To investigate the utility of MII-pH in the clinical investigation of patients with gastroesophageal reflux disease (GERD) symptoms.

METHODS

32 consecutive patients underwent 24-hour ambulatory MII-pH. 16 patients were on PPI (PPI+) therapy and 16 were taking no acid-suppressive medication (PPI-). We investigated the pattern of reflux by means of acid and nonacid reflux and the relation to typical and atypical symptoms. In addition, we investigated the symptom association by using the symptom index.

RESULTS

Symptom-related acid reflux was higher in the PPI+ group (33 vs. 25%) and symptom-related nonacid reflux was higher in the PPI- group (36 vs. 21%). The association between type of symptoms and the association to reflux is highly significant (p < 0.001) in the PPI- group. In this group the association of acid reflux is more likely to correlate with typical symptoms and the association of nonacid reflux is more likely to be associated with atypical symptoms.

CONCLUSIONS

These data show that nonacid reflux can be associated with symptoms in patients with GERD symptoms. The diagnostic value of MII-pH is independent of PPI therapy.

Authors+Show Affiliations

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany. jochen.weigt@medizin.uni-magdeburg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

17827936

Citation

Weigt, J, et al. "Multichannel Intraluminal Impedance and pH-metry for Investigation of Symptomatic Gastroesophageal Reflux Disease." Digestive Diseases (Basel, Switzerland), vol. 25, no. 3, 2007, pp. 179-82.
Weigt J, Mönkemüller K, Peitz U, et al. Multichannel intraluminal impedance and pH-metry for investigation of symptomatic gastroesophageal reflux disease. Dig Dis. 2007;25(3):179-82.
Weigt, J., Mönkemüller, K., Peitz, U., & Malfertheiner, P. (2007). Multichannel intraluminal impedance and pH-metry for investigation of symptomatic gastroesophageal reflux disease. Digestive Diseases (Basel, Switzerland), 25(3), pp. 179-82.
Weigt J, et al. Multichannel Intraluminal Impedance and pH-metry for Investigation of Symptomatic Gastroesophageal Reflux Disease. Dig Dis. 2007;25(3):179-82. PubMed PMID: 17827936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multichannel intraluminal impedance and pH-metry for investigation of symptomatic gastroesophageal reflux disease. AU - Weigt,J, AU - Mönkemüller,K, AU - Peitz,U, AU - Malfertheiner,P, PY - 2007/9/11/pubmed PY - 2007/10/25/medline PY - 2007/9/11/entrez SP - 179 EP - 82 JF - Digestive diseases (Basel, Switzerland) JO - Dig Dis VL - 25 IS - 3 N2 - BACKGROUND: Combined multichannel intraluminal impedance and pH-metry (MII-pH) is a technique that enables monitoring of gastroesophageal reflux independent of its acidity. AIM: To investigate the utility of MII-pH in the clinical investigation of patients with gastroesophageal reflux disease (GERD) symptoms. METHODS: 32 consecutive patients underwent 24-hour ambulatory MII-pH. 16 patients were on PPI (PPI+) therapy and 16 were taking no acid-suppressive medication (PPI-). We investigated the pattern of reflux by means of acid and nonacid reflux and the relation to typical and atypical symptoms. In addition, we investigated the symptom association by using the symptom index. RESULTS: Symptom-related acid reflux was higher in the PPI+ group (33 vs. 25%) and symptom-related nonacid reflux was higher in the PPI- group (36 vs. 21%). The association between type of symptoms and the association to reflux is highly significant (p < 0.001) in the PPI- group. In this group the association of acid reflux is more likely to correlate with typical symptoms and the association of nonacid reflux is more likely to be associated with atypical symptoms. CONCLUSIONS: These data show that nonacid reflux can be associated with symptoms in patients with GERD symptoms. The diagnostic value of MII-pH is independent of PPI therapy. SN - 1421-9875 UR - https://www.unboundmedicine.com/medline/citation/17827936/Multichannel_intraluminal_impedance_and_pH_metry_for_investigation_of_symptomatic_gastroesophageal_reflux_disease_ L2 - https://www.karger.com?DOI=10.1159/000103881 DB - PRIME DP - Unbound Medicine ER -