TY - JOUR T1 - Usefulness of a serological panel test in the assessment of gastritis in symptomatic children. AU - de Angelis,Gian Luigi, AU - Cavallaro,Lucas Giovanni, AU - Maffini,Valentina, AU - Moussa,Ali Mahamat, AU - Fornaroli,Fabiola, AU - Liatopoulou,Stefania, AU - Bizzarri,Barbara, AU - Merli,Roberta, AU - Comparato,Giuseppe, AU - Caruana,Pietro, AU - Cavestro,Giulia Martina, AU - Franzé,Angelo, AU - Di Mario,Francesco, PY - 2007/9/11/pubmed PY - 2007/10/25/medline PY - 2007/9/11/entrez SP - 206 EP - 13 JF - Digestive diseases (Basel, Switzerland) JO - Dig Dis VL - 25 IS - 3 N2 - BACKGROUND: Non-invasive methods are advisable for the detection of Helicobacter pylori-related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-H. pylori antibodies (IgG-Hp) have been proposed as a 'serological gastric biopsy'. AIM: To assess H. pylori infection and to evaluate gastric mucosa status in a pediatric population by means of serological parameters such as sPGI, sPGII, G-17 and IgG-Hp. METHODS: 45 consecutively children evaluated for upper gastrointestinal symptoms were analyzed. All children were submitted to upper gastrointestinal endoscopy with biopsies. Serum samples were analyzed for IgG-Hp, sPGII, sPGI and G-17 (Biohit, Helsinki, Finland). RESULTS: 18 children had H. pylori-related mild or moderate non-atrophic chronic gastritis. They presented significantly higher mean levels of sPGII and of IgG-Hp than negative ones, either under or up to 10 years. sPGI showed significantly increased levels in H. pylori-positive patients only over 10 years. G-17 levels were not different between H. pylori-positive and -negative ones. The best cut-offs of IgG-Hp, sPGII and of product IgG-Hp x sPGII, to identify H. pylori infection, were 30 IU/l, 9 microg/l, and 241 IU/l x microg/l, respectively. The product IgG-Hp x sPGII identified H. pylori infection with a 100% sensitivity, 92% specificity, 90% positive predictive value and 100% negative predictive value. IgG-Hp and IgG-Hp showed a correlation (r = 0.94; p < 0.001). CONCLUSIONS: Combined analysis of sPGII and IgG-Hp antibody levels could be recommended as a non-invasive panel for the assessment of H. pylori-related histological alterations of gastric mucosa in childhood. SN - 1421-9875 UR - https://www.unboundmedicine.com/medline/citation/17827941/Usefulness_of_a_serological_panel_test_in_the_assessment_of_gastritis_in_symptomatic_children_ L2 - https://www.karger.com?DOI=10.1159/000103886 DB - PRIME DP - Unbound Medicine ER -