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Small intestinal bacterial overgrowth: diagnosis and treatment.
Dig Dis. 2007; 25(3):237-40.DD

Abstract

Small intestinal bacterial overgrowth (SIBO) is a clinical condition characterized by a malabsorption syndrome due to an increase in microorganisms within the small intestine. The main mechanisms restricting bacterial colonization in the upper gut are the gastric acid barrier, mucosal and systemic immunity and intestinal clearance. When these mechanisms fail, bacterial overgrowth develops. Diarrhea, steatorrhea, chronic abdominal pain, bloating and flatulence are common symptoms and are similar to those observed in irritable bowel syndrome. Breath tests (glucose and/or lactulose breath tests) have been proposed as a sensitive and simple tool for the diagnosis of bacterial overgrowth, being non-invasive and inexpensive compared to the gold standard represented by the culture of intestinal aspirates. Antibiotic therapy is the cornerstone of SIBO treatment. Current SIBO treatment is based on empirical courses of broad-spectrum antibiotics since few controlled studies concerning the choice and duration of antibiotic therapy are available at present.

Authors+Show Affiliations

Internal Medicine Department, Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy. angiologia@rm.unicatt.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17827947

Citation

Gasbarrini, Antonio, et al. "Small Intestinal Bacterial Overgrowth: Diagnosis and Treatment." Digestive Diseases (Basel, Switzerland), vol. 25, no. 3, 2007, pp. 237-40.
Gasbarrini A, Lauritano EC, Gabrielli M, et al. Small intestinal bacterial overgrowth: diagnosis and treatment. Dig Dis. 2007;25(3):237-40.
Gasbarrini, A., Lauritano, E. C., Gabrielli, M., Scarpellini, E., Lupascu, A., Ojetti, V., & Gasbarrini, G. (2007). Small intestinal bacterial overgrowth: diagnosis and treatment. Digestive Diseases (Basel, Switzerland), 25(3), 237-40.
Gasbarrini A, et al. Small Intestinal Bacterial Overgrowth: Diagnosis and Treatment. Dig Dis. 2007;25(3):237-40. PubMed PMID: 17827947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small intestinal bacterial overgrowth: diagnosis and treatment. AU - Gasbarrini,Antonio, AU - Lauritano,Ernesto Cristiano, AU - Gabrielli,Maurizio, AU - Scarpellini,Emidio, AU - Lupascu,Andrea, AU - Ojetti,Veronica, AU - Gasbarrini,Giovanni, PY - 2007/9/11/pubmed PY - 2007/10/25/medline PY - 2007/9/11/entrez SP - 237 EP - 40 JF - Digestive diseases (Basel, Switzerland) JO - Dig Dis VL - 25 IS - 3 N2 - Small intestinal bacterial overgrowth (SIBO) is a clinical condition characterized by a malabsorption syndrome due to an increase in microorganisms within the small intestine. The main mechanisms restricting bacterial colonization in the upper gut are the gastric acid barrier, mucosal and systemic immunity and intestinal clearance. When these mechanisms fail, bacterial overgrowth develops. Diarrhea, steatorrhea, chronic abdominal pain, bloating and flatulence are common symptoms and are similar to those observed in irritable bowel syndrome. Breath tests (glucose and/or lactulose breath tests) have been proposed as a sensitive and simple tool for the diagnosis of bacterial overgrowth, being non-invasive and inexpensive compared to the gold standard represented by the culture of intestinal aspirates. Antibiotic therapy is the cornerstone of SIBO treatment. Current SIBO treatment is based on empirical courses of broad-spectrum antibiotics since few controlled studies concerning the choice and duration of antibiotic therapy are available at present. SN - 1421-9875 UR - https://www.unboundmedicine.com/medline/citation/17827947/Small_intestinal_bacterial_overgrowth:_diagnosis_and_treatment_ L2 - https://www.karger.com?DOI=10.1159/000103892 DB - PRIME DP - Unbound Medicine ER -