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Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA.
J Mol Evol 2007; 65(3):289-95JM

Abstract

Systematic investigation into the chemical etiology of ribose has led to the discovery of glycerol nucleic acid (GNA) and threose nucleic acid (TNA) as possible progenitor candidates of RNA in the origins of life. Coupled with their chemical simplicity, polymers for both systems are capable of forming stable Watson-Crick antiparallel duplex structures with themselves and RNA, thereby providing a mechanism for the transfer of genetic information between successive genetic systems. Investigation into whether both polymers arose independently or descended from a common evolutionary pathway would provide additional constraints on models that describe the emergence of a hypothetical RNA world. Here we show by thermal denaturation that complementary GNA and TNA mixed sequence polymers are unable, even after prolonged incubation times, to adopt stable helical structures by intersystem cross-pairing. This experimental observation suggests that GNA and TNA, whose structures derive from one another, were not consecutive polymers in the same evolutionary pathway to RNA.

Authors+Show Affiliations

The Center for BioOptical Nanotechnology, The Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17828568

Citation

Yang, Ying-Wei, et al. "Experimental Evidence That GNA and TNA Were Not Sequential Polymers in the Prebiotic Evolution of RNA." Journal of Molecular Evolution, vol. 65, no. 3, 2007, pp. 289-95.
Yang YW, Zhang S, McCullum EO, et al. Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. J Mol Evol. 2007;65(3):289-95.
Yang, Y. W., Zhang, S., McCullum, E. O., & Chaput, J. C. (2007). Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. Journal of Molecular Evolution, 65(3), pp. 289-95.
Yang YW, et al. Experimental Evidence That GNA and TNA Were Not Sequential Polymers in the Prebiotic Evolution of RNA. J Mol Evol. 2007;65(3):289-95. PubMed PMID: 17828568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. AU - Yang,Ying-Wei, AU - Zhang,Su, AU - McCullum,Elizabeth O, AU - Chaput,John C, Y1 - 2007/09/09/ PY - 2006/12/18/received PY - 2007/04/25/accepted PY - 2007/9/11/pubmed PY - 2008/1/12/medline PY - 2007/9/11/entrez SP - 289 EP - 95 JF - Journal of molecular evolution JO - J. Mol. Evol. VL - 65 IS - 3 N2 - Systematic investigation into the chemical etiology of ribose has led to the discovery of glycerol nucleic acid (GNA) and threose nucleic acid (TNA) as possible progenitor candidates of RNA in the origins of life. Coupled with their chemical simplicity, polymers for both systems are capable of forming stable Watson-Crick antiparallel duplex structures with themselves and RNA, thereby providing a mechanism for the transfer of genetic information between successive genetic systems. Investigation into whether both polymers arose independently or descended from a common evolutionary pathway would provide additional constraints on models that describe the emergence of a hypothetical RNA world. Here we show by thermal denaturation that complementary GNA and TNA mixed sequence polymers are unable, even after prolonged incubation times, to adopt stable helical structures by intersystem cross-pairing. This experimental observation suggests that GNA and TNA, whose structures derive from one another, were not consecutive polymers in the same evolutionary pathway to RNA. SN - 0022-2844 UR - https://www.unboundmedicine.com/medline/citation/17828568/Experimental_evidence_that_GNA_and_TNA_were_not_sequential_polymers_in_the_prebiotic_evolution_of_RNA_ L2 - https://dx.doi.org/10.1007/s00239-007-9017-9 DB - PRIME DP - Unbound Medicine ER -