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An attempt to produce experimental tuberculoid leprosy in the nine-banded armadillo.
Indian J Lepr. 1991 Apr-Jun; 63(2):159-65.IJ

Abstract

In an attempt to produce experimental tuberculoid leprosy, three nine-banded armadillos, two with borderline tuberculoid lepromin reaction, and one with tuberculoid lepromin reaction, were chosen. They were injected subcutaneously in a four square centimetre area in the abdominal skin with saline suspension of 6.5 x 10(7) M. leprae. Induration of skin at the injected site appeared in 24 hours and persisted for 6 months in one and for 18 months in the other two animals. Histopathological examination of the infected site at 6 weeks, 18 and 20 months showed progressively decreasing granulomatous inflammation; but the cutaneous nerves were uninvolved. Autopsy examination of the three animals failed to show disseminated disease. Since there was no evidence of nerve involvement, experimental transmission of tuberculoid leprosy to armadillos could not be established in this study.

Authors+Show Affiliations

Laboratory Research Branch, Gillis W Long Hansen's Disease Center, Carville, Louisiana 70721.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1783786

Citation

Job, C K., et al. "An Attempt to Produce Experimental Tuberculoid Leprosy in the Nine-banded Armadillo." Indian Journal of Leprosy, vol. 63, no. 2, 1991, pp. 159-65.
Job CK, Sanchez RM, Hastings RC. An attempt to produce experimental tuberculoid leprosy in the nine-banded armadillo. Indian J Lepr. 1991;63(2):159-65.
Job, C. K., Sanchez, R. M., & Hastings, R. C. (1991). An attempt to produce experimental tuberculoid leprosy in the nine-banded armadillo. Indian Journal of Leprosy, 63(2), 159-65.
Job CK, Sanchez RM, Hastings RC. An Attempt to Produce Experimental Tuberculoid Leprosy in the Nine-banded Armadillo. Indian J Lepr. 1991 Apr-Jun;63(2):159-65. PubMed PMID: 1783786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An attempt to produce experimental tuberculoid leprosy in the nine-banded armadillo. AU - Job,C K, AU - Sanchez,R M, AU - Hastings,R C, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 159 EP - 65 JF - Indian journal of leprosy JO - Indian J Lepr VL - 63 IS - 2 N2 - In an attempt to produce experimental tuberculoid leprosy, three nine-banded armadillos, two with borderline tuberculoid lepromin reaction, and one with tuberculoid lepromin reaction, were chosen. They were injected subcutaneously in a four square centimetre area in the abdominal skin with saline suspension of 6.5 x 10(7) M. leprae. Induration of skin at the injected site appeared in 24 hours and persisted for 6 months in one and for 18 months in the other two animals. Histopathological examination of the infected site at 6 weeks, 18 and 20 months showed progressively decreasing granulomatous inflammation; but the cutaneous nerves were uninvolved. Autopsy examination of the three animals failed to show disseminated disease. Since there was no evidence of nerve involvement, experimental transmission of tuberculoid leprosy to armadillos could not be established in this study. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/1783786/An_attempt_to_produce_experimental_tuberculoid_leprosy_in_the_nine_banded_armadillo_ DB - PRIME DP - Unbound Medicine ER -