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Transfusion-associated microchimerism.
Vox Sang. 2007 Oct; 93(3):188-95.VS

Abstract

Blood transfusion is a newly recognized cause of microchimerism, the stable persistence of a minor population of allogeneic cells. Relatively recent advances in polymerase chain reaction technology have spawned new information about the frequency and aetiology of transfusion-associated microchimerism (TA-MC). Although conceptually related to fetal-maternal microchimerism, TA-MC is a distinct and separate entity. Evidence of TA-MC has been strongest among patients with severe traumatic injuries who receive relatively fresh blood products shortly after an episode of massive haemorrhage. The presence of a focal deficit in the cellular immunologic repertoire prior to transfusion that happens to match a blood donor's human leucocyte antigen type also appears to be an important predisposing factor. TA-MC seems to be common (affecting approximately 10% of transfused injured patients), enduring (lasting years to decades) and pronounced (involving up to 5% of circulating leucocytes and multiple immunophenotypic lineages suggestive of haematopoietic engraftment). Further study of this topic may reveal important information regarding potential clinical consequences of TA-MC, as well as basic haematologic and immunologic processes.

Authors+Show Affiliations

Department of Surgery, UC, Davis Medical Center, Sacramento, CA 95817, USA. garth.utter@ucdmc.ucdavis.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17845255

Citation

Utter, G H., et al. "Transfusion-associated Microchimerism." Vox Sanguinis, vol. 93, no. 3, 2007, pp. 188-95.
Utter GH, Reed WF, Lee TH, et al. Transfusion-associated microchimerism. Vox Sang. 2007;93(3):188-95.
Utter, G. H., Reed, W. F., Lee, T. H., & Busch, M. P. (2007). Transfusion-associated microchimerism. Vox Sanguinis, 93(3), 188-95.
Utter GH, et al. Transfusion-associated Microchimerism. Vox Sang. 2007;93(3):188-95. PubMed PMID: 17845255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transfusion-associated microchimerism. AU - Utter,G H, AU - Reed,W F, AU - Lee,T-H, AU - Busch,M P, PY - 2007/9/12/pubmed PY - 2007/11/14/medline PY - 2007/9/12/entrez SP - 188 EP - 95 JF - Vox sanguinis JO - Vox Sang VL - 93 IS - 3 N2 - Blood transfusion is a newly recognized cause of microchimerism, the stable persistence of a minor population of allogeneic cells. Relatively recent advances in polymerase chain reaction technology have spawned new information about the frequency and aetiology of transfusion-associated microchimerism (TA-MC). Although conceptually related to fetal-maternal microchimerism, TA-MC is a distinct and separate entity. Evidence of TA-MC has been strongest among patients with severe traumatic injuries who receive relatively fresh blood products shortly after an episode of massive haemorrhage. The presence of a focal deficit in the cellular immunologic repertoire prior to transfusion that happens to match a blood donor's human leucocyte antigen type also appears to be an important predisposing factor. TA-MC seems to be common (affecting approximately 10% of transfused injured patients), enduring (lasting years to decades) and pronounced (involving up to 5% of circulating leucocytes and multiple immunophenotypic lineages suggestive of haematopoietic engraftment). Further study of this topic may reveal important information regarding potential clinical consequences of TA-MC, as well as basic haematologic and immunologic processes. SN - 0042-9007 UR - https://www.unboundmedicine.com/medline/citation/17845255/Transfusion_associated_microchimerism_ L2 - https://doi.org/10.1111/j.1423-0410.2007.00954.x DB - PRIME DP - Unbound Medicine ER -