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Post-traumatic stress disorder among adolescents with bipolar disorder and its relationship to suicidality.
Bipolar Disord. 2007 Sep; 9(6):649-55.BD

Abstract

OBJECTIVES

The aims of this cross-sectional pilot study were to ascertain the rates of post-traumatic stress disorder (PTSD) among adolescents with bipolar disorder (BPD) and major depressive disorder (MDD) relative to a comparison group comprised of non-affectively ill patients, and to determine whether PTSD is related to suicidal ideation and attempts. The impetus for the study was born of clinical impressions derived in the course of routine clinical practice.

METHODS

Patients were screened by a single interviewer for BPD, MDD and PTSD, panic disorder, obsessive-compulsive disorder (OCD) and social phobia using the apposite modules from the Structured Clinical Interview for DSM-IV (SCID) and histories of suicidal ideation and attempts. The data were subjected to analysis using a logistic regression model.

RESULTS

The database included 34 patients with BPD, 79 with MDD and 26 with a non-affective disorder. The risk for PTSD for a patient with BPD significantly exceeded that for a patient with MDD [odds ratio (OR) = 4.9, 95% confidence interval (CI) = 1.9-12.2, p = 0.001]. Patients with PTSD had an insignificantly increased risk for suicidal ideation (OR = 2.8, 95% CI = 0.9-8.9, p = 0.069), and a 4.5-fold significantly increased risk of having had a suicide attempt (OR = 4.5, 95% CI = 1.7-11.7, p = 0.002). The relationship between PTSD and suicide attempts remained significant even after controlling for the confounding effects of concurrent panic disorder, OCD and social phobia (OR = 3.4, 95% CI = 1.1-10.0, p = 0.023).

CONCLUSIONS

Patients with BPD have a greater risk for PTSD than those with MDD. Post-traumatic stress disorder is significantly related to history of suicide attempts.

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Authors+Show Affiliations

Dilsaver SC
Mental Health Mental Retardation Clinic, Rio Grande City, TX, USA. stevendilsaver@aol.com
Benazzi F
No affiliation info available
Akiskal HS
No affiliation info available
Akiskal KK
No affiliation info available

MeSH

AdolescentBipolar DisorderComorbidityCross-Sectional StudiesDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleHumansLife Change EventsMalePilot ProjectsPsychiatric Status Rating ScalesRisk FactorsStress Disorders, Post-TraumaticSuicide, Attempted

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17845281

Citation

Dilsaver, Steven C., et al. "Post-traumatic Stress Disorder Among Adolescents With Bipolar Disorder and Its Relationship to Suicidality." Bipolar Disorders, vol. 9, no. 6, 2007, pp. 649-55.
Dilsaver SC, Benazzi F, Akiskal HS, et al. Post-traumatic stress disorder among adolescents with bipolar disorder and its relationship to suicidality. Bipolar Disord. 2007;9(6):649-55.
Dilsaver, S. C., Benazzi, F., Akiskal, H. S., & Akiskal, K. K. (2007). Post-traumatic stress disorder among adolescents with bipolar disorder and its relationship to suicidality. Bipolar Disorders, 9(6), 649-55.
Dilsaver SC, et al. Post-traumatic Stress Disorder Among Adolescents With Bipolar Disorder and Its Relationship to Suicidality. Bipolar Disord. 2007;9(6):649-55. PubMed PMID: 17845281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-traumatic stress disorder among adolescents with bipolar disorder and its relationship to suicidality. AU - Dilsaver,Steven C, AU - Benazzi,Franco, AU - Akiskal,Hagop S, AU - Akiskal,Kareen K, PY - 2007/9/12/pubmed PY - 2007/12/20/medline PY - 2007/9/12/entrez SP - 649 EP - 55 JF - Bipolar disorders JO - Bipolar Disord VL - 9 IS - 6 N2 - OBJECTIVES: The aims of this cross-sectional pilot study were to ascertain the rates of post-traumatic stress disorder (PTSD) among adolescents with bipolar disorder (BPD) and major depressive disorder (MDD) relative to a comparison group comprised of non-affectively ill patients, and to determine whether PTSD is related to suicidal ideation and attempts. The impetus for the study was born of clinical impressions derived in the course of routine clinical practice. METHODS: Patients were screened by a single interviewer for BPD, MDD and PTSD, panic disorder, obsessive-compulsive disorder (OCD) and social phobia using the apposite modules from the Structured Clinical Interview for DSM-IV (SCID) and histories of suicidal ideation and attempts. The data were subjected to analysis using a logistic regression model. RESULTS: The database included 34 patients with BPD, 79 with MDD and 26 with a non-affective disorder. The risk for PTSD for a patient with BPD significantly exceeded that for a patient with MDD [odds ratio (OR) = 4.9, 95% confidence interval (CI) = 1.9-12.2, p = 0.001]. Patients with PTSD had an insignificantly increased risk for suicidal ideation (OR = 2.8, 95% CI = 0.9-8.9, p = 0.069), and a 4.5-fold significantly increased risk of having had a suicide attempt (OR = 4.5, 95% CI = 1.7-11.7, p = 0.002). The relationship between PTSD and suicide attempts remained significant even after controlling for the confounding effects of concurrent panic disorder, OCD and social phobia (OR = 3.4, 95% CI = 1.1-10.0, p = 0.023). CONCLUSIONS: Patients with BPD have a greater risk for PTSD than those with MDD. Post-traumatic stress disorder is significantly related to history of suicide attempts. SN - 1398-5647 UR - https://www.unboundmedicine.com/medline/citation/17845281/Post_traumatic_stress_disorder_among_adolescents_with_bipolar_disorder_and_its_relationship_to_suicidality_ L2 - https://doi.org/10.1111/j.1399-5618.2007.00396.x DB - PRIME DP - Unbound Medicine ER -