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Association of polymorphisms of human leucocyte antigen-DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese.
Int J Immunogenet. 2007 Oct; 34(5):373-8.IJ

Abstract

To investigate whether human leucocyte antigen (HLA) class II DQA1 and DQB1 gene polymorphisms are associated with chronic hepatitis B virus (HBV) infection and development of HBV-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC), we detected the DQA1 and DQB1 allele polymorphisms in 168 HBV carriers (including 48 chronic hepatitis B, 42 LC and 78 HCC patients) and 100 controls who had recovered from HBV infection by using polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Our data suggest that DQA1*0102 and DQA1*0104 were associated with protection from chronic HBV infection (P(c) = 0.003) and development of LC (P(c) = 0.001), respectively, whereas DQB1*0201 conferred susceptible effect on chronic HBV infection (P(c) = 0.008). We also found that DQA1*0601, DQB1*0601 and DQA1*0201 showed some susceptible effect on chronic HBV infection and LC, respectively, however, these associations were no longer significant after Bonferroni correction (P(c) = 0.390, P(c) = 0.475 and P(c) = 0.140, respectively). No significant association has been found between DQA1 and DQB1 alleles and development of HCC. These results indicate that different subtypes of HLA-DQA1 and DQB1 are associated with development of chronic HBV infection and LC, respectively, in Han Chinese population.

Authors+Show Affiliations

Department of Gastroenterology, Shandong University Qilu Hospital, Jinan, Shandong, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17845309

Citation

Liu, C, and B Cheng. "Association of Polymorphisms of Human Leucocyte antigen-DQA1 and DQB1 Alleles With Chronic Hepatitis B Virus Infection, Liver Cirrhosis and Hepatocellular Carcinoma in Chinese." International Journal of Immunogenetics, vol. 34, no. 5, 2007, pp. 373-8.
Liu C, Cheng B. Association of polymorphisms of human leucocyte antigen-DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese. Int J Immunogenet. 2007;34(5):373-8.
Liu, C., & Cheng, B. (2007). Association of polymorphisms of human leucocyte antigen-DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese. International Journal of Immunogenetics, 34(5), 373-8.
Liu C, Cheng B. Association of Polymorphisms of Human Leucocyte antigen-DQA1 and DQB1 Alleles With Chronic Hepatitis B Virus Infection, Liver Cirrhosis and Hepatocellular Carcinoma in Chinese. Int J Immunogenet. 2007;34(5):373-8. PubMed PMID: 17845309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of polymorphisms of human leucocyte antigen-DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese. AU - Liu,C, AU - Cheng,B, PY - 2007/9/12/pubmed PY - 2007/12/21/medline PY - 2007/9/12/entrez SP - 373 EP - 8 JF - International journal of immunogenetics JO - Int J Immunogenet VL - 34 IS - 5 N2 - To investigate whether human leucocyte antigen (HLA) class II DQA1 and DQB1 gene polymorphisms are associated with chronic hepatitis B virus (HBV) infection and development of HBV-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC), we detected the DQA1 and DQB1 allele polymorphisms in 168 HBV carriers (including 48 chronic hepatitis B, 42 LC and 78 HCC patients) and 100 controls who had recovered from HBV infection by using polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Our data suggest that DQA1*0102 and DQA1*0104 were associated with protection from chronic HBV infection (P(c) = 0.003) and development of LC (P(c) = 0.001), respectively, whereas DQB1*0201 conferred susceptible effect on chronic HBV infection (P(c) = 0.008). We also found that DQA1*0601, DQB1*0601 and DQA1*0201 showed some susceptible effect on chronic HBV infection and LC, respectively, however, these associations were no longer significant after Bonferroni correction (P(c) = 0.390, P(c) = 0.475 and P(c) = 0.140, respectively). No significant association has been found between DQA1 and DQB1 alleles and development of HCC. These results indicate that different subtypes of HLA-DQA1 and DQB1 are associated with development of chronic HBV infection and LC, respectively, in Han Chinese population. SN - 1744-3121 UR - https://www.unboundmedicine.com/medline/citation/17845309/Association_of_polymorphisms_of_human_leucocyte_antigen_DQA1_and_DQB1_alleles_with_chronic_hepatitis_B_virus_infection_liver_cirrhosis_and_hepatocellular_carcinoma_in_Chinese_ L2 - https://doi.org/10.1111/j.1744-313X.2007.00702.x DB - PRIME DP - Unbound Medicine ER -